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  1. Article

    Open Access

    Value of ultra-high field MRI in patients with suspected focal epilepsy and negative 3 T MRI (EpiUltraStudy): protocol for a prospective, longitudinal therapeutic study

    Resective epilepsy surgery is a well-established, evidence-based treatment option in patients with drug-resistant focal epilepsy. A major predictive factor of good surgical outcome is visualization and delinea...

    R. H. G. J. van Lanen, C. J. Wiggins, A. J. Colon, W. H. Backes… in Neuroradiology (2022)

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  2. No Access

    Article

    Functional hemispherectomy: postoperative motor state and correlation to preoperative DTI

    Functional hemispherectomy (FH) is an infrequent method to reduce seizure frequency in patients with intractable epilepsy. The risk that hemispherotomy injures brain structures involved in residual motor funct...

    M. Nelles, H. Urbach, R. Sassen, J. C. Schöne-Bake, H. Tschampa… in Neuroradiology (2015)

  3. No Access

    Article

    Seizure outcome, functional outcome, and quality of life after hemispherectomy in adults

    Functional hemispherectomy is a well-established method in childhood epilepsy surgery with only a few reports on its application in adults.

    J. Schramm, D. Delev, J. Wagner, C. E. Elger, M. von Lehe in Acta Neurochirurgica (2012)

  4. No Access

    Chapter and Conference Paper

    Pseudo-Homozygous APC Resistance Due to Coinheritance of Heterozygous Factor V — R506Q and Type I Deficiency Associated with Thrombosis

    Resistance to activated protein C (APC resistance) is the most frequent inherited hypercoagulable state that represents a common risk factor for venous thrombosis [1]. This resistance is due to a G > A substituti...

    Frau A. Pavlova, Dr. R. Loreth, D. Delev, Prof. J. Oldenburg in 37th Hemophilia Symposium (2008)

  5. No Access

    Chapter and Conference Paper

    Structural Investigation of Two Novel Mutations in Coagulation Factor V by Molecular Modeling

    Human coagulation factor V (FV) provides an essential function in the coagulation pathway. As a non-enzymatic cofactor of the prothrombinase complex, it is required for the rapid generation of thrombin [1, 2]. Th...

    D. Delev, A. Pavlova, E. Seifried, Prof. J. Oldenburg in 37th Hemophilia Symposium (2008)

  6. No Access

    Chapter and Conference Paper

    Molecular Genetic Analysis in Patients with Inherited Factor V Deficiency

    Identifying the molecular basis of mutations underlying this rare coagulation disorder will aid to obtain more insight into the mechanisms involved in the variable clinical phenotype of patients with FV defici...

    A. Pavlova, D. Delev, E. Seifried, J. Oldenburg in 36th Hemophilia Symposium Hamburg 2005 (2007)

  7. No Access

    Chapter and Conference Paper

    Rapid and Sensitive Detection of Heterozygous Deletions of one or more Exons in Hemophilia A Females by Multiplex PCR and DHPLC Technique

    In conclusion MP/DHPLC technique can reliable identify hemophilia A female carriers, harboring FVIII gene copy number aberrations and it appears to be a powerful tool in genetic concealing of hemophilia families.

    A. Pavlova, J. Schröder, D. Delev, C. R. Müller… in 36th Hemophilia Symposium Hamburg 2005 (2007)

  8. No Access

    Chapter and Conference Paper

    Denaturing High Performance Liquid Chromatography Represents an Efficient Technique for Detection of Heterozygous Large Deletions in Antithrombin Gene

    The detection of large gene deletions and rearrangements in AT gene is essential in order to provide an appropriate genetic counseling and treatment in antithrombin deficient patients. We have developed a DHPL...

    A. Pavlova, O. El-Maarri, B. Luxembourg, E. Lindhoff-Last… in 35th Hemophilia Symposium (2006)

  9. No Access

    Chapter and Conference Paper

    Pharmacological and Toxicological Investigations on the New Bulgarian Drug Lonetil

    Lonetil is a new tranquilizer with great therapeutic range. With its influence on the pentylenetetrazol seizures, hypothermal effect and depression of provoked fight it is similar to the classic tranquilizers....

    L. Daleva, D. Stefanova, O. Angelova, S. Zarcova… in Toxicological Aspects of Food Safety (1978)