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Article
General analysis of competitive binding in drug–interceptor–DNA systems
A general model of competitive binding in drug–interceptor–DNA systems has been developed in order to quantify both the interceptor and protector mechanisms. The model involves full parameterization of the bas...
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Article
Quantification of the interceptor action of caffeine on the in vitro biological effect of the anti-tumour agent topotecan
Using published in vitro data on the dependence of the percentage of apoptosis induced by the anti-cancer drug topotecan in a leukaemia cell line on the concentration of added caffeine, and a general model of ...
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Article
Complexation of Biologically Active Aromatic Compounds with DNA in the Presence of Theophylline
1H NMR measurements (500 MHz) have been used to determine the equilibrium hetero-association constants of theophylline (THP) with various biologically active aromatic compounds (daunomyci...
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Article
Complexation of anthracycline drugs with DNA in the presence of caffeine
The competitive binding of anthracycline antitumour drugs, [daunomycin (DAU), doxorubicin (DOX) or nogalamycin (NOG)], with caffeine (CAF) to a model DNA oligomer has been investigated by 500 MHz 1H NMR spectrosc...
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Article
Complexation of the quinolone antibiotic norfloxacin with DNA
1H-NMR spectroscopy (500 MHz) was used to study the complexation of the antibacterial agent norfloxacin (NOR) with DNA tetramers 5′-d(TpGpCpA) and 5′-d(CpGpCpG) in aqueous solution. For t...
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Article
A Structural and Thermodynamic Analysis of Novatrone and Flavin Mononucleotide Heteroassociation in Aqueous Solution by 1H NMR Spectroscopy
A heteroassociation of the antitumor antibiotic novatrone (NOV) and flavin mononucleotide (FMN) in aqueous solution was studied by one- and two-dimentional 1H NMR spectroscopy (500 MHz) to elucidate the molecular...
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Article
Structural analysis of the complex of phenoxazone antibiotic actinocyl-bis(2-dimethylaminoethyl)amide with deoxytetranucleotide 5′-d(TpGpCpA) by two-dimensional 1H-NMR spectroscopy and molecular mechanics
The spatial structure of an intercalated complex of the synthetic phenoxazone antibiotic actinocyl-bis-(2-dimethylaminoethyl)amide (ActII) and the self-complementary deoxytetranucleotide 5′-d(TpGpCpA) was stud...
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Article
Heteroassociation of Caffeine with the Antibiotic Actinocyl- bis(3-dimethylaminopropylamine) in Aqueous Solution: 1H NMR Analysis
The heteroassociation of caffeine (CAF) and the synthetic antibiotic actinocyl-bis(3-dimethylaminopropylamine) (ACT) was studied in aqueous solution by one- and two-dimensional 1H NMR spectroscopy at 500 MHz. The...
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Article
NMR Study of Complexation of Aromatic Ligands with Heptadeoxynucleotide 5"-d(GCGAAGC) Forming Stable Hairpin Structure in Aqueous Solution
Complex formation of hairpin-producing heptadeoxynucleotide 5"-d(GCGAAGC) with aromatic molecules: acridine dye proflavine and anthracycline antibiotic daunomycin was studied by one-dimensional 1H NMR and two-dim...
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Article
The Self-Association of Antibiotic Actinocyl-bis(3-dimethylaminopropylamine) in Aqueous Solution: A 1H NMR Analysis
The self-association of the synthetic antibiotic actinocyl-bis(3-dimethylaminopropylamine) was studied in aqueous solution by one- and two-dimensional 1H NMR spectroscopy at 500 MHz. The two-dimensional homonucle...
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Article
NMR Study of Daunomycin Complexation with Hexadeoxynucleotide 5"-d(TpApCpGpTpA) in Aqueous Solution
Self-association of hexadeoxynucleotide 5"-d(TpApCpGpTpA) and its complexation with antitumor antibiotic daunomycin were studied by one- and two-dimensional homonuclear 1H NMR spectroscopy and heteronuclear 1H–31