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  1. No Access

    Article

    Altered naive and memory CD4+ T-cell homeostasis and immunosenescence characterize younger patients with myelodysplastic syndrome

    Response to immunosuppressive therapy (IST) in younger patients with myelodysplastic syndrome (MDS) has been linked to a T-cell-dominant autoimmune process that impairs hematopoiesis. Analysis of the age-adjus...

    J X Zou, D E Rollison, D Boulware, D-T Chen, E M Sloand, L V Pfannes… in Leukemia (2009)

  2. No Access

    Article

    Prevalence and clinical association of clonal T-cell expansions in Myelodysplastic Syndrome

    Selected patients with Myelodysplastic Syndromes (MDS) are responsive to immunosuppressive therapy, suggesting that hematopoietic suppressive T cells have a pathogenic role in ineffective hematopoiesis. We ass...

    P K Epling-Burnette, J S Painter, D E Rollison, E Ku, D Vendron, R Widen… in Leukemia (2007)

  3. No Access

    Article

    The farnesyl transferase inhibitor, FTI-277, inhibits growth and induces apoptosis in drug-resistant myeloma tumor cells

    Mutations of the ras gene are among the most commonly identified transforming events in human cancers, including multiple myeloma. Farnesyltransferase inhibitors (FTI) were developed to prevent Ras processing and...

    S C E Bolick, T H Landowski, D Boulware, M M Oshiro, J Ohkanda, A D Hamilton… in Leukemia (2003)