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Article
Open AccessSpatiotemporal changes of the aridity index in **njiang over the past 60 years
The Aridity Index (AI), calculated from 99 homogeneous meteorological stations from 1961 to 2020, was used to analyze the variation of dryness/wetness climate change in **njiang in the past 60 years. The resul...
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Article
Open AccessAnalysis on the temporal and spatial characteristics of the shallow soil temperature of the Qinghai-Tibet Plateau
Shallow soil refers to the soil layer within the 50 cm depth. Shallow soil temperature (ST) directly or indirectly affects many processes in the soil, such as seed germination, plant growth, and water evaporat...
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Article
Open AccessOncohistone interactome profiling uncovers contrasting oncogenic mechanisms and identifies potential therapeutic targets in high grade glioma
Histone H3 mutations at amino acids 27 (H3K27M) and 34 (H3G34R) are recurrent drivers of pediatric-type high-grade glioma (pHGG). H3K27M mutations lead to global disruption of H3K27me3 through dominant negativ...
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Article
Variability of Sea Ice from 2008 to 2019 in the Bohai and Northern Huanghai Sea, China and the Relationship with Climatic Factors
Sea ice has important effect on the marine ecosystem and people living in the surrounding regions in winter. However, the understanding on changes of sea ice in the Bohai and northern Huanghai Sea (BNHS), Chin...
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Article
Open AccessGlioma stem cells invasive phenotype at optimal stiffness is driven by MGAT5 dependent mechanosensing
Glioblastomas stem-like cells (GSCs) by invading the brain parenchyma, remains after resection and radiotherapy and the tumoral microenvironment become stiffer. GSC invasion is reported as stiffness sensitive ...
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Article
Quantifying the non-conservative production of potential temperature over the past 22 000 years
The energy budgets of the ocean play a crucial role in the analysis of climate change. Potential temperature is traditionally used as a conservative quantity to express variations associated with “heat” in oce...
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Article
Subtropical countercurrent variations in cooling climates induced by freshwater forcing over the subarctic North Atlantic
The subtropical countercurrent (STCC) could affect ocean eddy activity and the atmosphere above. How the STCC varied in a cooling scenario, such as the stadials during the last deglaciation (19–11 ka; ka = 100...
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Article
Contributions of the Bering Strait throughflow to oceanic meridional heat transport under modern and Last Glacial Maximum climate conditions
Paleo reconstructions and model simulations have suggested the Bering Strait plays a pivotal role in climate change. However, the contribution of the Bering Strait throughflow to oceanic meridional heat transp...
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Article
Open AccessMetabolic Reprogramming by Hexosamine Biosynthetic and Golgi N-Glycan Branching Pathways
De novo uridine-diphosphate-N-acetylglucosamine (UDP-GlcNAc) biosynthesis requires glucose, glutamine, acetyl-CoA and uridine, however GlcNAc salvaged from glycoconjugate turnover and dietary sources also makes a...
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Article
The day-to-day monitoring of the 2011 severe drought in China
Dry/wet condition has a large interannual variability. Decision-makers need to know the onset, duration, and intensity of drought, and require droughts be monitored at a daily to weekly scale. However, previou...
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Article
Temporal regulation of EGF signalling networks by the scaffold protein Shc1
Cell-surface receptors frequently use scaffold proteins to recruit cytoplasmic targets, but the rationale for this is uncertain. Activated receptor tyrosine kinases, for example, engage scaffolds such as Shc1 ...
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Article
Potential impacts of East Asian winter monsoon on climate variability and predictability in the Australian summer monsoon region
This study explores potential impacts of the East Asian winter monsoon (EAWM) on summer climate variability and predictability in the Australia–Asian region through Australia–Asia (A-A) monsoon interactions. O...
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Article
Phosphorylation regulates the stability of the regulatory CK2β subunit
Protein kinase CK2 is a protein serine/threonine kinase that exhibits elevated expression in a number of cancers and displays oncogenic activity in mice. The regulatory CK2β subunit has a central role in assem...
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Article
Functional specialization of CK2 isoforms and characterization of isoform-specific binding partners
In mammals, protein kinase CK2 has two isozymic forms of its catalytic subunit, designated CK2αgr; and CK2α′. CK2α and CK2α′ exhibit extensive similarity within their catalytic domains but have completely unre...
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Functional specialization of CK2 isoforms and characterization of isoform-specific binding partners
In mammals, protein kinase CK2 has two isozymic forms of its catalytic subunit, designated CK2α and CK2α’. CK2α and CK2α’ exhibit extensive similarity within their catalytic domains but have completely unrelat...
