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  1. No Access

    Article

    Use of cholesterol-rich nanoparticles that bind to lipoprotein receptors as a vehicle to paclitaxel in the treatment of breast cancer: pharmacokinetics, tumor uptake and a pilot clinical study

    In animal experiments paclitaxel oleate associated with a cholesterol-rich nanoemulsion concentrated in the neoplastic tissues and showed reduced toxicity and increased antitumor activity compared with paclita...

    Luís A. Pires, Roberto Hegg, Claudete J. Valduga… in Cancer Chemotherapy and Pharmacology (2009)

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    Article

    Plasma kinetics of a cholesterol-rich microemulsion (LDE) in patients with Hodgkin’s and non-Hodgkin’s lymphoma and a preliminary study on the toxicity of etoposide associated with LDE

    Background: Neoplastic diseases are often associated with low plasma low-density lipoprotein (LDL) cholesterol and diminished LDL clearance due to upregulation in cancer cells of the rece...

    Ketlin V. Pinheiro, Vania T. M. Hungria… in Cancer Chemotherapy and Pharmacology (2006)

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    Article

    Improvement of paclitaxel therapeutic index by derivatization and association to a cholesterol-rich microemulsion: in vitro and in vivo studies

    A cholesterol-rich microemulsion or nanoparticle termed LDE concentrates in cancer tissues after injection into the bloodstream. Here the cytotoxicity, pharmacokinetics, toxicity to animals and therapeutic act...

    Debora G. Rodrigues, Durvanei A. Maria… in Cancer Chemotherapy and Pharmacology (2005)