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  1. Article

    Open Access

    The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistance

    In this study, the impact of the apolipoprotein B mRNA-editing catalytic subunit-like (APOBEC) enzyme APOBEC3B (A3B) on epidermal growth factor receptor (EGFR)-driven lung cancer was assessed. A3B expression in E...

    Deborah R. Caswell, Philippe Gui, Manasi K. Mayekar, Emily K. Law… in Nature Genetics (2024)

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  2. No Access

    Article

    Lung adenocarcinoma promotion by air pollutants

    A complete understanding of how exposure to environmental substances promotes cancer formation is lacking. More than 70 years ago, tumorigenesis was proposed to occur in a two-step process: an initiating step ...

    William Hill, Emilia L. Lim, Clare E. Weeden, Claudia Lee, Marcellus Augustine… in Nature (2023)

  3. No Access

    Article

    Flow cytometric single cell-based assay to simultaneously detect cell death, cell cycling, DNA content and cell senescence

    Cell death, cell cycle arrest and cellular senescence are three distinct cellular responses that can be induced by oncogene activation and diverse anti-cancer agents, and this often requires the action of the ...

    Elizabeth Lieschke, Zilu Wang, Catherine Chang… in Cell Death & Differentiation (2022)

  4. Article

    Open Access

    Preclinical small molecule WEHI-7326 overcomes drug resistance and elicits response in patient-derived xenograft models of human treatment-refractory tumors

    Targeting cell division by chemotherapy is a highly effective strategy to treat a wide range of cancers. However, there are limitations of many standard-of-care chemotherapies: undesirable drug toxicity, side-...

    Christoph Grohmann, Francesca Walker, Mark Devlin, Meng-**ao Luo… in Cell Death & Disease (2021)

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  5. No Access

    Article

    Characterization of a novel human BFL-1-specific monoclonal antibody

    Lahiru Gangoda, Charis E. Teh, Michael A. Dengler… in Cell Death & Differentiation (2020)

  6. No Access

    Article

    Dual inhibition of BCL-XL and MCL-1 is required to induce tumour regression in lung squamous cell carcinomas sensitive to FGFR inhibition

    Genetic alterations in the fibroblast growth factor receptors (FGFRs) have been described in multiple solid tumours including bladder cancer, head and neck and lung squamous cell carcinoma (SqCC). However, rec...

    Clare E. Weeden, Casey Ah-Cann, Aliaksei Z. Holik, Julie Pasquet… in Oncogene (2018)

  7. No Access

    Article

    Investigating the roles of regulatory T cells, mast cells and interleukin-9 in the control of skin inflammation by vitamin D

    Topical application of biologically active vitamin D [1,25-dihydroxyvitamin D (1,25(OH)2D)], or low-calcemic analogues, curb skin inflammation through mechanisms that involve migratory dendritic cells (DCs) and r...

    Shelley Gorman, Sian Geldenhuys, Clare E. Weeden… in Archives of Dermatological Research (2018)

  8. Article

    Open Access

    Vitamin D and allergic airway disease shape the murine lung microbiome in a sex-specific manner

    Vitamin D is under scrutiny as a potential regulator of the development of respiratory diseases characterised by chronic lung inflammation, including asthma and chronic obstructive pulmonary disease. It has an...

    Michael Roggenbuck, Denise Anderson, Kenneth Klingenberg Barfod… in Respiratory Research (2016)

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