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Chunlei **g
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Article
Technology Optimization Analysis of Three-Roll Rotary Piercing Process for Seamless Steel Pipe
A three-roll rotary piercing process (TRPP) with severe plastic deformation was conducted to fabricate stainless steel seamless tubes with high mechanical properties. To address production issues such as front...
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Open AccessALKBH5 regulates chicken adipogenesis by mediating LCAT mRNA stability depending on m6A modification
Previous studies have demonstrated the role of N6-methyladenosine (m6A) RNA methylation in various biological processes, our research is the first to elucidate its specific impact on LCAT mRNA stability and adipo...
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Open AccessAssociation between metal exposures and periodontitis among U.S. adults: the potential mediating role of biological aging
This study aimed to investigate the associations between metal exposures and periodontitis among U.S. adults, as well as the mediated effect of biological aging.
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Comparison of secondary hydrothermal and pyrolysis in biomass carbon-based materials: activation methods and surface properties
Functional carbon-based materials play an important role in the field of energy and environmental protection, and how to prepare high-performance sustainable carbon-based materials is a current research hot sp...
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Open AccessComprehensive evaluation of drought tolerance of six Chinese chestnut varieties (clones) based on flavonoids and other physiological indexes
Flavonoids are crucial secondary metabolites that possess the ability to mitigate UV damage and withstand both biotic and abiotic stresses. Therefore, it is of immense significance to investigate the flavonoid...
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Population pharmacokinetics of free and liposome-encapsulated mitoxantrone in patients with relapsed/refractory lymphoma or small cell lung cancer
This study is aimed at investigating the pharmacokinetic (PK) characteristics of pegylated liposomal mitoxantrone (PLM) in patients with relapsed/refractory lymphoma or small cell lung cancer (SCLC) by constru...
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Open AccessIdentifying stance in legislative discourse: a corpus-driven study of data protection laws
Mirroring public ideologies and value systems in legislative discourse, stance not only functions as a powerful instrument for legislators to balance legal values and stakeholders’ interests but also acts as a...
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Open AccessAssociations between the TyG index and the ɑ-Klotho protein in middle-aged and older population relevant to diabetes mellitus in NHANES 2007–2016
The anti-aging protein Klotho has diverse functions in antioxidative stress and energy metabolism through several pathways. While it has been reported that α-Klotho is downregulated in patients with insulin re...
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Multidisciplinary and multiscale nanoscience research roadmap based on large scientific facilities
With the advancement of modern science and technology, large scientific facilities are increasingly oriented toward demand and application, and can be used for basic research as well as serving multiple discip...
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Open AccessIntracranial EEG signals disentangle multi-areal neural dynamics of vicarious pain perception
Empathy enables understanding and sharing of others’ feelings. Human neuroimaging studies have identified critical brain regions supporting empathy for pain, including the anterior insula (AI), anterior cingul...
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Assessment of fuel characteristics and combustion dynamics of hydrochar produced via hydrothermal carbonization of brown algal biomass
In this study, Laminaria japonica (LJ) was transformed into biochar via hydrothermal carbonization (HTC), and the physicochemical properties, combustion characteristics, and kinetics of the resulting hydrochar we...
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Open AccessA novel PH1/pE27HGFK1 nanoparticles for orthotopic glioblastoma therapy
The therapeutic resistance to ionizing radiation (IR) and angiogenesis inhibitors is a great challenge for clinicians in the treatment of glioblastoma, which is associated with Hepatocyte growth factor (HGF)/M...
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Open AccessLigand-mediate exciton allocation enables efficient cluster-based white light-emitting diodes via single and heavy do**
Despite potential in high-resolution and low-cost displays and lighting, multi-do** structures and low concentrations (<1%) limit repeatability and stability of single-emissive-layer white light-emitting dev...
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Open AccessSafety and efficacy of multi-target TKI combined with nivolumab in check-point inhibitor-refractory patients with advanced NSCLC: a prospective, single-arm, two-stage study
Resistance to immune checkpoint inhibitors (ICIs) represents a major unmet medical need in non-small cell lung cancer (NSCLC) patients. Vascular endothelial growth factor (VEGF) inhibition may reverse a suppre...
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Acacetin targets STING to alleviate the destabilization of the medial meniscus-induced osteoarthritis in mice
Osteoarthritis (OA) is a common joint disorder affecting about 7% of the global population, primarily characterized by the gradual loss of articular cartilage. This degeneration results from local inflammation...
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Open AccessPotential role of salivary lactic acid bacteria in pathogenesis of oral lichen planus
Emerging evidence emphasized the role of oral microbiome in oral lichen planus (OLP). To date, no dominant pathogenic bacteria have been identified consistently. It is noteworthy that a decreased abundance of Str...
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Characteristics of shear thickening fluid and its application in engineering: a state-of-the-art review
Shear thickening fluid (STF), a type of non-Newtonian fluid, becomes more viscous as the strain rate rises. Due to their unique rheological properties, STFs have outstanding vibration-dam** and energy-absorb...
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Pan-Cancer Analysis and Experimental Validation of CEND1 as a Prognostic and Immune Infiltration-Associated Biomarker for Gliomas
Cell cycle exit and neuronal differentiation 1 (CEND1), highly expressed in the brain, is a specific transmembrane protein which plays a tumor suppressor role. This study is performed to investigate the role o...
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Diagnostic Study of an Extreme Explosive Cyclone over the Kuroshio/Kuroshio Extension Region
Explosive cyclones (ECs) occur frequently over the Kuroshio/Kuroshio Extension region. The most rapidly intensified EC over the Kuroshio/Kuroshio Extension region during the 42 years (1979–2020) of cold season...
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Exploring Antarctic subglacial lakes with RECoverable Autonomous Sonde (RECAS): Design and first field tests
Conducting scientific drilling on subglacial lakes and obtaining samples of subglacial lake water holds great significance in unraveling the formation and evolution of Antarctic subglacial lakes and early Eart...
