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Article
Open AccessSpatiotemporal control of genome engineering in cone photoreceptors
Cones are essential for color recognition, high resolution, and central vision; therefore cone death causes blindness. Understanding the pathophysiology of each cell type in the retina is key to develo** the...
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Article
PKM2 ablation enhanced retinal function and survival in a preclinical model of retinitis pigmentosa
Retinitis pigmentosa (RP) is a neurodegenerative disorder that causes irreversible vision loss in over 1.5 million individuals world-wide. The genetic heterogeneity of RP necessitates a broad therapy that is a...
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Article
Mechanisms of neurodegeneration in a preclinical autosomal dominant retinitis pigmentosa knock-in model with a RhoD190N mutation
D190N, a missense mutation in rhodopsin, causes photoreceptor degeneration in patients with autosomal dominant retinitis pigmentosa (adRP). Two competing hypotheses have been developed to explain why D190N rod ph...
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Article
Open AccessGene Therapy Restores Mfrp and Corrects Axial Eye Length
Hyperopia (farsightedness) is a common and significant cause of visual impairment, and extreme hyperopia (nanophthalmos) is a consequence of loss-of-function MFRP mutations. MFRP deficiency causes abnormal eye gr...
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Article
Open AccessNeuroretinal hypoxic signaling in a new preclinical murine model for proliferative diabetic retinopathy
Diabetic retinopathy (DR) affects approximately one-third of diabetic patients and, if left untreated, progresses to proliferative DR (PDR) with associated vitreous hemorrhage, retinal detachment, iris neovasc...
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Article
One-pot green hydrothermal synthesis of fluorescent nitrogen-doped carbon nanodots for in vivo bioimaging
One-pot green synthesis of fluorescent nitrogen-doped carbon nanodots (CNDs) was developed by hydrothermal treatments of biocompatible polyvinylpyrrolidone (PVP) and glycine. The fluorescent nitrogen-doped CND...
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Chapter
Genome Editing in the Retina: A Case Study in CRISPR for a Patient-Specific Autosomal Dominant Retinitis Pigmentosa Model
The future of precision medicine, genome editing has gained momentum in the field of ophthalmology because of the eye’s amenability to genetic interventions. The eye is an ideal target for gene therapy due to ...
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Article
Elucidation of the DNA-interacting properties and anticancer activity of a Ni(II)-coordinated mithramycin dimer complex
Mithramycin (Mith) forms a drug-metal complex with a 2:1 stoichiometry by chelation with a Ni(II) ion, which was determined using circular dichroism spectroscopy. Mith exhibits an increased affinity (~55 fold)...
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Article
Open AccessLong-term Safety and Efficacy of Human-Induced Pluripotent Stem Cell (iPS) Grafts in a Preclinical Model of Retinitis Pigmentosa
The U.S. Food and Drug Administration recently approved phase I/II clinical trials for embryonic stem (ES) cell-based retinal pigmented epithelium (RPE) transplantation, but this allograft transplantation requ...
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Article
Open AccessMice with a D190N Mutation in the Gene Encoding Rhodopsin: A Model for Human Autosomal-Dominant Retinitis Pigmentosa
Rhodopsin is the G protein-coupled receptor in charge of initiating signal transduction in rod photoreceptor cells upon the arrival of the photon. D190N (RhoD190n), a missense mutation in rhodopsin, causes autoso...
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Article
Simpler Throughput Analysis of CDMA/Unslotted ALOHA Radio Networks with Variable Message Length Based on M/M/inf Queueing Model
We propose a new and exact method to analyze the throughput of the DS CDMA unslotted ALOHA system with variable number of fixed-length packets. The proposed scheme requires two-dimensional summation while the ...
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Chapter and Conference Paper
Interference-Free Coexistence among Heterogenous Devices in the 60 GHz Band
With its abundant bandwidth and worldwide availability, the 60 GHz band has been considered as a promising solution to provide multi-Gbps wireless transmission. Different standard bodies and industrial interes...
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Article
Open AccessComparative analysis of differentially expressed genes in normal and white spot syndrome virus infected Penaeus monodon
White spot syndrome (WSS) is a viral disease that affects most of the commercially important shrimps and causes serious economic losses to the shrimp farming industry worldwide. However, little information is ...
