-
Article
Open AccessIL-37d suppresses Rheb-mTORC1 axis independently of TCS2 to alleviate alcoholic liver disease
Tuberous sclerosis complex 2 (TSC2) crucially suppresses Rheb activity to prevent mTORC1 activation. However, mutations in TSC genes lead to mTORC1 overactivation, thereby causing various developmental disorde...
-
Article
Open AccessCorrection: Classical swine fever virus triggers RIG-I and MDA5-dependent signaling pathway to IRF-3 and NF-κB activation to promote secretion of interferon and inflammatory cytokines in porcine alveolar macrophages
-
Article
Open AccessWhat are the differences in paraspinal muscle morphometry among degenerative spondylolisthesis patients, isthmic spondylolisthesis patients, and healthy individuals? A propensity score matching analysis
To compare the morphometry of paraspinal muscles in patients with degenerative spondylolisthesis (DS), isthmic spondylolisthesis (IS), and healthy individuals.
-
Article
Open AccessSignal enhancement ratio of multi-phase contrast-enhanced MRI: an imaging biomarker for survival in pancreatic adenocarcinoma
To evaluate signal enhancement ratio (SER) for tissue characterization and prognosis stratification in pancreatic adenocarcinoma (PDAC), with quantitative histopathological analysis (QHA) as the reference stan...
-
Article
Open AccessRisk factors for renal outcomes in children with antineutrophil cytoplasmic antibody-associated vasculitis: a nationwide retrospective study in China
Pediatric antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is a life-threatening systemic vasculitis featured by liability to renal involvement. However, there are few studies on the risk factor...
-
Article
Open AccessThoracolumbar fractures patients undergoing posterior pedicle screw fixation can benefit from drainage
To explore whether it is necessary to put drain tubes after posterior pedicle screw fixation of thoracolumbar fractures.
-
Article
Open AccessYoung osteocyte-derived extracellular vesicles facilitate osteogenesis by transferring tropomyosin-1
Bone marrow mesenchymal stem cells (BMSCs) can undergo inadequate osteogenesis or excessive adipogenesis as they age due to changes in the bone microenvironment, ultimately resulting in decreased bone density ...
-
Article
Open AccessIncreased serum asprosin is correlated with diabetes mellitus-induced erectile dysfunction
Asprosin, a newly identified adipokine, is pathologically increased in type 2 diabetes. The aim of this study is to see whether serum asprosin concentrations are linked to diabetes mellitus-induced erectile dy...
-
Article
Open AccessAZGP1 deficiency promotes angiogenesis in prostate cancer
Loss of AZGP1 expression is a biomarker associated with progression to castration resistance, development of metastasis, and poor disease-specific survival in prostate cancer. However, high expression of AZGP1...
-
Article
Open AccessAuthor Correction: Transcriptomics-based investigation of manganese dioxide nanoparticle toxicity in rats’ choroid plexus
-
Article
Open AccessAssembly of short amphiphilic peptoids into nanohelices with controllable supramolecular chirality
A long-standing challenge in bioinspired materials is to design and synthesize synthetic materials that mimic the sophisticated structures and functions of natural biomaterials, such as helical protein assembl...
-
Article
Open AccessSerum PYCARD may become a new diagnostic marker for rheumatoid arthritis patients
The objective of this investigation is to analyze the levels and clinical relevance of serum PYCARD (Pyrin and CARD domain-containing protein, commonly known as ASC—apoptosis-associated speck-like protein cont...
-
Article
Open AccessEnhanced polarization switching characteristics of HfO2 ultrathin films via acceptor-donor co-do**
In the realm of ferroelectric memories, HfO2-based ferroelectrics stand out because of their exceptional CMOS compatibility and scalability. Nevertheless, their switchable polarization and switching speed are not...
-
Article
Open AccessConstructing regulable supports via non-stoichiometric engineering to stabilize ruthenium nanoparticles for enhanced pH-universal water splitting
Establishing appropriate metal-support interactions is imperative for acquiring efficient and corrosion-resistant catalysts for water splitting. Herein, the interaction mechanism between Ru nanoparticles and a...
-
Article
Open AccessImpact of ecological migration village construction on vector mosquito and mosquito-borne disease in the southern Yunnan Province, China
To evaluate the influence of ecological migration village construction on mosquito vector populations and mosquito-borne diseases in southern Yunnan Province. Two vicinal villages in Mengla County, the souther...
-
Article
Open AccessA late eating midpoint is associated with increased risk of diabetic kidney disease: a cross-sectional study based on NHANES 2013–2020
Modifying diet is crucial for diabetes and complication management. Numerous studies have shown that adjusting eating habits to align with the circadian rhythm may positively affect metabolic health. However, ...
-
Article
Open AccessSerotonergic modulation of vigilance states in zebrafish and mice
Vigilance refers to being alertly watchful or paying sustained attention to avoid potential threats. Animals in vigilance states reduce locomotion and have an enhanced sensitivity to aversive stimuli so as to ...
-
Article
Open AccessArchitecture of symbiotic dinoflagellate photosystem I–light-harvesting supercomplex in Symbiodinium
Symbiodinium are the photosynthetic endosymbionts for corals and play a vital role in supplying their coral hosts with photosynthetic products, forming the nutritional foundation for high-yield coral reef ecosyst...
-
Article
Open AccessA genoty** array for the globally invasive vector mosquito, Aedes albopictus
Although whole-genome sequencing (WGS) is the preferred genoty** method for most genomic analyses, limitations are often experienced when studying genomes characterized by a high percentage of repetitive ele...
-
Article
Microstructure and properties of LZQT600-3 HCCDIBs for plunger pump cylinder
It is important to improve the comprehensive performance of the ductile iron bars (DIBs) for the cylinder block of the extra high pressure hydraulic plunger pump and accelerate the industrial application. In t...
