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Article
Microstructure and properties of LZQT600-3 HCCDIBs for plunger pump cylinder
It is important to improve the comprehensive performance of the ductile iron bars (DIBs) for the cylinder block of the extra high pressure hydraulic plunger pump and accelerate the industrial application. In t...
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Article
Association of air pollutants and meteorological factors with tuberculosis: a national multicenter ecological study in China
The impact of weather variability and air pollutants on tuberculosis (TB) has been a research hotspot. Previous studies have mostly been limited to a certain area or with a small sample size of cases, and mult...
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Article
Dipyridamole enhances the anti-cancer ability of aspirin against colorectal cancer by inducing apoptosis in an unfolded protein response-dependent manner
Available evidence indicates that dipyridamole enhances the anti-thrombotic effects of aspirin for the prevention of secondary strokes. Aspirin is a well-known non-steroid anti-inflammatory drug. This anti-inf...
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Article
Study on anisotropy of microstructure and mechanical properties of AZ31 magnesium alloy fabricated by wire arc additive manufacturing
Based on wire arc additive manufacturing (WAAM) technology, AZ31 magnesium alloy in bulk was successfully fabricated, and its microstructure as well as mechanical properties in different planes were observed a...
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Article
Open AccessCoadaptation fostered by the SLIT2-ROBO1 axis facilitates liver metastasis of pancreatic ductal adenocarcinoma
To explore the mechanism of coadaptation and the potential drivers of pancreatic ductal adenocarcinoma (PDAC) metastasis to the liver, we study key molecules involved in this process and their translational va...
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Article
CTHRC1 promotes liver metastasis by resha** infiltrated macrophages through physical interactions with TGF-β receptors in colorectal cancer
Metastasis is a major cause of cancer-related deaths. Tumor-intrinsic properties can determine whether tumor metastasis occurs or not. Here, by comparing the gene expression patterns in primary colorectal canc...
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Article
Open AccessSingle-cell RNA sequencing reveals that targeting HSP90 suppresses PDAC progression by restraining mitochondrial bioenergetics
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers, which lacks effective treatment strategies. There is an urgent need for the development of new strategies for PDAC therapy. The genetic ...
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Article
Open AccessIdentification of a subset of immunosuppressive P2RX1-negative neutrophils in pancreatic cancer liver metastasis
The immunosuppressive microenvironment that is shaped by hepatic metastatic pancreatic ductal adenocarcinoma (PDAC) is essential for tumor cell evasion of immune destruction. Neutrophils are important componen...
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Article
Microstructure and properties of ductile iron bars for plunger pump prepared by horizontal continuous casting process
Ductile iron bars (DIBs) with a diameter of 145 mm, used for plunger pump production, were made by the horizontal continuous casting (HCC). The microstructure of the samples cut at three locations with differe...
