29 Result(s)

Article

IP3R2-mediated Ca²⁺ release promotes LPS-induced cardiomyocyte pyroptosis via the activation of NLRP3/Caspase-1/GSDMD pathway

Pyroptosis plays a crucial role in sepsis, and the abnormal handling of myocyte calcium (Ca²⁺) has been associated with cardiomyocyte pyroptosis. Specifically, the inositol 1,4,5-trisphosphate receptor type 2 (IP...

Qing-Rui Wu, Hui Yang, Hui-Dan Zhang, Yong-Jiang Cai… in Cell Death Discovery (2024)

Article

A chromosome-level genome assembly of Hong Kong catfish (Clarias fuscus) uncovers a sex-determining region

Hong Kong catfish (Clarias fuscus) is an ecologically and economically important species that is widely distributed in freshwater regions of southern China. Hong Kong catfish has significant sexual growth dimorph...

Chang-Xu Tian, **ng-Hua Lin, Da-Yan Zhou, Yu Chen, Yi-Jun Shen, Ming-Hui Ye… in BMC Genomics (2023)

Article

Colonization with ubiquitous protist Blastocystis ST1 ameliorates DSS-induced colitis and promotes beneficial microbiota and immune outcomes

Blastocystis is a species complex that exhibits extensive genetic diversity, evidenced by its classification into several genetically distinct subtypes (ST). Although several studies have shown the relationships ...

Lei Deng, Lukasz Wojciech, Chin Wen Png… in npj Biofilms and Microbiomes (2023)

Article

Correction: CRISPR FISHer enables high-sensitivity imaging of nonrepetitive DNA in living cells through phase separation-mediated signal amplification

**n-Yuan Lyu, Yuan Deng, **ao-Yan Huang, Zhen-Zhen Li, Guo-Qing Fang… in Cell Research (2022)

Article

Targeting UHRF1-SAP30-MXD4 axis for leukemia initiating cell eradication in myeloid leukemia

Aberrant self-renewal of leukemia initiation cells (LICs) drives aggressive acute myeloid leukemia (AML). Here, we report that UHRF1, an epigenetic regulator that recruits DNMT1 to methylate DNA, is highly exp...

Cheng-Long Hu, Bing-Yi Chen, Zijuan Li, Tianbiao Yang, Chun-Hui Xu… in Cell Research (2022)

Article

CRISPR FISHer enables high-sensitivity imaging of nonrepetitive DNA in living cells through phase separation-mediated signal amplification

The dynamic three-dimensional structures of chromatin and extrachromosomal DNA molecules regulate fundamental cellular processes and beyond. However, the visualization of specific DNA sequences in live cells, ...

**n-Yuan Lyu, Yuan Deng, **ao-Yan Huang, Zhen-Zhen Li, Guo-Qing Fang… in Cell Research (2022)

Article

Low dose inocula of SARS-CoV-2 Alpha variant transmits more efficiently than earlier variants in hamsters

Emerging variants of SARS-CoV-2 have been shown to rapidly replace original circulating strains in humans soon after they emerged. There is a lack of experimental evidence to explain how these natural occurrin...

Bobo Wing-Yee Mok, Honglian Liu, Shaofeng Deng, Jiayan Liu… in Communications Biology (2021)

Article

Photoreceptor protection by mesenchymal stem cell transplantation identifies exosomal MiR-21 as a therapeutic for retinal degeneration

Photoreceptor apoptosis is recognized as one key pathogenesis of retinal degeneration, the counteraction of which represents a promising approach to safeguard visual function. Recently, mesenchymal stem cell t...

Chun-Lei Deng, Cheng-Biao Hu, Sheng-Tao Ling, Na Zhao… in Cell Death & Differentiation (2021)

Article

High glucose induces Drp1-mediated mitochondrial fission via the Orai1 calcium channel to participate in diabetic cardiomyocyte hypertrophy

Mitochondrial dysfunction and impaired Ca²⁺ handling are involved in the development of diabetic cardiomyopathy (DCM). Dynamic relative protein 1 (Drp1) regulates mitochondrial fission by changing its level of ph...

Qing-Rui Wu, Dan-Lin Zheng, Pei-Ming Liu, Hui Yang, Lu-An Li… in Cell Death & Disease (2021)

Article

FNDC5 alleviates oxidative stress and cardiomyocyte apoptosis in doxorubicin-induced cardiotoxicity via activating AKT

Oxidative stress and cardiomyocyte apoptosis play critical roles in doxorubicin (DOX)-induced cardiotoxicity. Previous studies indicated that fibronectin type III domain-containing 5 (FNDC5) and its cleaved fo...

**n Zhang, Can Hu, Chun-Yan Kong, Peng Song, Hai-Ming Wu… in Cell Death & Differentiation (2020)

Article

The paracrine induction of prostate cancer progression by caveolin-1

A subpopulation of cancer stem cells (CSCs) plays a critical role of cancer progression, recurrence, and therapeutic resistance. Many studies have indicated that castration-resistant prostate cancer (CRPC) is ...

Chun-Jung Lin, Eun-** Yun, U-Ging Lo, Yu-Ling Tai, Su Deng… in Cell Death & Disease (2019)

Article

Oridonin protects against cardiac hypertrophy by promoting P21-related autophagy

Autophagy is an endogenous protective process; the loss of autophagy could destabilize proteostasis and elevate intracellular oxidative stress, which is critically involved in the development of cardiac hypert...

Man Xu, Chun-xia Wan, Si-hui Huang, Hui-bo Wang, Di Fan… in Cell Death & Disease (2019)

Article

FSCN1 is an effective marker of poor prognosis and a potential therapeutic target in human tongue squamous cell carcinoma

To estimate the value of FSCN1 in evaluating the prognosis and guiding the targeted therapy for patients with tongue squamous cell carcinoma (TSCC). Using the Oncomine database, we found some genes especially ...

Yue Chen, Tian Tian, Zhi-Yong Li, Chun-Yang Wang, Rong Deng… in Cell Death & Disease (2019)

Article

Distinct multilevel misregulations of Parkin and PINK1 revealed in cell and animal models of TDP-43 proteinopathy

Parkin and PINK1 play an important role in mitochondrial quality control, whose malfunction may also be involved in the pathogenesis of amyotrophic lateral sclerosis (ALS). Excessive TDP-43 accumulation is a p...

**ng Sun, Yongjia Duan, Caixia Qin, Jian-Chiuan Li, Gang Duan… in Cell Death & Disease (2018)