13 Result(s)
within
Chulhee Choi
Science, Humanities and Social Sciences, multidisciplinary
English
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Article
Open AccessBlockade of integrin α3 attenuates human pancreatic cancer via inhibition of EGFR signalling
The prognosis of pancreatic cancer remains dismal despite continuous and considerable efforts. Integrins (ITGs) are highly expressed in various malignant cancers. However, very few studies investigated the rol...
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Article
Open AccessRobust method for identification of prognostic gene signatures from gene expression profiles
In the last decade, many attempts have been made to use gene expression profiles to identify prognostic genes for various types of cancer. Previous studies evaluating the prognostic value of genes suffered by ...
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Article
Open AccessAutocrine DUSP28 signaling mediates pancreatic cancer malignancy via regulation of PDGF-A
Pancreatic cancer remains one of the most deadly cancers with a grave prognosis. Despite continuous efforts to improve remedial values, limited progress has been made. We have reported that dual specificity ph...
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Article
Open AccessThree-dimensional label-free imaging and quantification of lipid droplets in live hepatocytes
Lipid droplets (LDs) are subcellular organelles with important roles in lipid storage and metabolism and involved in various diseases including cancer, obesity, and diabetes. Conventional methods, however, hav...
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Article
Open AccessExosome engineering for efficient intracellular delivery of soluble proteins using optically reversible protein–protein interaction module
Nanoparticle-mediated delivery of functional macromolecules is a promising method for treating a variety of human diseases. Among nanoparticles, cell-derived exosomes have recently been highlighted as a new th...
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Article
Open AccessEvaluation of drug-targetable genes by defining modes of abnormality in gene expression
In the post-genomic era, many researchers have taken a systematic approach to identifying abnormal genes associated with various diseases. However, the gold standard has not been established and most of these ...
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Article
Open AccessOptogenetic control of cell signaling pathway through scattering skull using wavefront sha**
We introduce a non-invasive approach for optogenetic regulation in biological cells through highly scattering skull tissue using wavefront sha**. The wavefront of the incident light was systematically contro...
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Article
Open AccessBlockade of dual-specificity phosphatase 28 decreases chemo-resistance and migration in human pancreatic cancer cells
Pancreatic cancer remains one of the most deadly cancers, with a grave prognosis. Despite numerous endeavors to improve treatment of the neoplasm, limited progress has been made. In the present study, we inves...
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Article
Open AccessCytosolic Irradiation of Femtosecond Laser Induces Mitochondria-dependent Apoptosis-like Cell Death via Intrinsic Reactive Oxygen Cascades
High-intensity femtosecond lasers have recently been used to irreversibly disrupt nanoscale structures, such as intracellular organelles and to modify biological functions in a reversible manner: so-called nan...
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Article
Open AccessTranscriptional regulation of adrenomedullin by oncostatin M in human astroglioma cells: Implications for tumor invasion and migration
Adrenomedullin (ADM), a secretory peptide with multiple functions in physiological to pathological conditions, is upregulated in several human cancers, including brain, breast, colon, prostate and lung cancer....
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Article
Open AccessIdentification of phenotype deterministic genes using systemic analysis of transcriptional response
Systemic identification of deterministic genes for different phenotypes is a primary application of high-throughput expression profiles. However, gene expression differences cannot be used when the differences...
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Article
Open AccessFluorescent microscopy beyond diffraction limits using speckle illumination and joint support recovery
Structured illumination microscopy (SIM) breaks the optical diffraction limit by illuminating a sample with a series of line-patterned light. Recently, in order to alleviate the requirement of precise knowledg...
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Article
Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II
Platelet-derived growth factor (PDGF) is a potent mitogenic and migratory factor that regulates the tyrosine phosphorylation of a variety of signalling proteins via intracellular production of H2O2 (refs 1, 2–3)....
