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Article
Open AccessExosome-mediated delivery of super-repressor IκBα alleviates inflammation and joint damages in rheumatoid arthritis
This study aims to investigate the potential anti-inflammatory effects of exosomes engineered to carry super-repressor IκB (Exo-srIκB), an exosome-based NF-κB inhibitor, in the context of RA.
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Article
Open AccessAtypical induction of HIF-1α expression by pericellular Notch1 signaling suffices for the malignancy of glioblastoma multiforme cells
Contact-based pericellular interactions play important roles in cancer progression via juxtacrine signaling pathways. The present study revealed that hypoxia-inducible factor-1α (HIF-1α), induced even in non-h...
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Article
Open AccessBiodistribution of Exosomes and Engineering Strategies for Targeted Delivery of Therapeutic Exosomes
Exosomes are cell-secreted nano-sized vesicles which deliver diverse biological molecules for intercellular communication. Due to their therapeutic potential, exosomes have been engineered in numerous ways for...
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Article
Open AccessBlockade of integrin α3 attenuates human pancreatic cancer via inhibition of EGFR signalling
The prognosis of pancreatic cancer remains dismal despite continuous and considerable efforts. Integrins (ITGs) are highly expressed in various malignant cancers. However, very few studies investigated the rol...
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Article
Open AccessBlood flow characteristics of diabetic patients with complications detected by optical measurement
Diabetes mellitus (DM) is one of the most common diseases worldwide. Uncontrolled and prolonged hyperglycemia can cause diabetic complications, which reduce the quality of life of patients. Diabetic complicati...
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Article
Open AccessRobust method for identification of prognostic gene signatures from gene expression profiles
In the last decade, many attempts have been made to use gene expression profiles to identify prognostic genes for various types of cancer. Previous studies evaluating the prognostic value of genes suffered by ...
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Article
Open AccessAutocrine DUSP28 signaling mediates pancreatic cancer malignancy via regulation of PDGF-A
Pancreatic cancer remains one of the most deadly cancers with a grave prognosis. Despite continuous efforts to improve remedial values, limited progress has been made. We have reported that dual specificity ph...
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Article
Rapid and quantitative measurement of cell adhesion and migration activity by time-series analysis on biomimetic topography
Glioblastoma Multiforme (GBM) is the most malignant brain tumor in adults, highly infiltrative and difficult to cure. According to the histopathological evidence, the glioma cells are found to infiltrate into ...
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Reference Work Entry In depth
Application of Ultrashort-Pulsed Lasers for Optical Manipulation of Biological Functions
Focused ultrashort laser pulses with high peak intensity cause nonlinear effects such as multiphoton absorption; therefore, multiphoton microscopy has used ultrashort-pulsed laser as a primary light source. Re...
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Article
Open AccessThree-dimensional label-free imaging and quantification of lipid droplets in live hepatocytes
Lipid droplets (LDs) are subcellular organelles with important roles in lipid storage and metabolism and involved in various diseases including cancer, obesity, and diabetes. Conventional methods, however, hav...
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Article
Open AccessExosome engineering for efficient intracellular delivery of soluble proteins using optically reversible protein–protein interaction module
Nanoparticle-mediated delivery of functional macromolecules is a promising method for treating a variety of human diseases. Among nanoparticles, cell-derived exosomes have recently been highlighted as a new th...
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Article
Combined inhibition of vascular endothelial growth factor receptor signaling with temozolomide enhances cytotoxicity against human glioblastoma cells via downregulation of Neuropilin-1
Glioblastoma multiforme (GBM) is the most common and aggressive type of primary brain tumor with grave prognosis. Despite the growing understanding of the complex signaling networks responsible for the initiat...
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Article
Open AccessEvaluation of drug-targetable genes by defining modes of abnormality in gene expression
In the post-genomic era, many researchers have taken a systematic approach to identifying abnormal genes associated with various diseases. However, the gold standard has not been established and most of these ...
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Article
Open AccessOptogenetic control of cell signaling pathway through scattering skull using wavefront sha**
We introduce a non-invasive approach for optogenetic regulation in biological cells through highly scattering skull tissue using wavefront sha**. The wavefront of the incident light was systematically contro...
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Article
Identification of novel trans-crosstalk between histone modifications via genome-wide analysis of maximal deletion effect
Crosstalk between epigenetic variables including histone modification produces diverse combinatorial patterns each of which has specific biological roles. Therefore, identification of causal relationships amon...
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Article
Open AccessBlockade of dual-specificity phosphatase 28 decreases chemo-resistance and migration in human pancreatic cancer cells
Pancreatic cancer remains one of the most deadly cancers, with a grave prognosis. Despite numerous endeavors to improve treatment of the neoplasm, limited progress has been made. In the present study, we inves...
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Article
Characterization of CD8+CD57+ T cells in patients with acute myocardial infarction
Although T cells are known to be involved in the pathogenesis of coronary artery disease, it is unclear which subpopulation of T cells contributes to pathogenesis in acute myocardial infarction (MI). We studie...
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Article
Open AccessCytosolic Irradiation of Femtosecond Laser Induces Mitochondria-dependent Apoptosis-like Cell Death via Intrinsic Reactive Oxygen Cascades
High-intensity femtosecond lasers have recently been used to irreversibly disrupt nanoscale structures, such as intracellular organelles and to modify biological functions in a reversible manner: so-called nan...
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Living Reference Work Entry In depth
Application of Ultrashort-Pulsed Lasers for Optical Manipulation of Biological Functions
Focused ultrashort laser pulses with high peak intensity cause nonlinear effects such as multiphoton absorption; therefore, multiphoton microscopy has used ultrashort-pulsed laser as a primary light source. Re...
-
Article
Open AccessTranscriptional regulation of adrenomedullin by oncostatin M in human astroglioma cells: Implications for tumor invasion and migration
Adrenomedullin (ADM), a secretory peptide with multiple functions in physiological to pathological conditions, is upregulated in several human cancers, including brain, breast, colon, prostate and lung cancer....
