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  1. No Access

    Article

    Toxicity and toxicokinetics of the cyclin-dependent kinase inhibitor AG-024322 in cynomolgus monkeys following intravenous infusion

    Cyclin-dependent kinases (CDKs) play a significant role in the control of cell-cycle progression and exhibit aberrant regulation in various neoplastic diseases. AG-024322 is a potent inhibitor of CDK1, CDK2, a...

    Alan P. Brown, Cynthia L. Courtney, Kay A. Criswell… in Cancer Chemotherapy and Pharmacology (2008)

  2. No Access

    Chapter

    The Detection of High Mass-to-Charge Biological Ions by Fourier Transform Mass Spectrometry: Issues and Routes for Instrument Improvement

    Although Fourier transform mass spectrometry (FTMS) has demonstrated the ability to trap biomolecular ions that have mass-to-charge ratios on the order of 150000, FTMS is seldom employed as a tool for the char...

    Christopher L. Holliman, Don L. Rempel… in Mass Spectrometry in Biomolecular Sciences (1996)

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    Chapter

    Fourier Transform Mass Spectrometry: Features, Principles, Capabilities, and Limitations

    Although a comparably young area of mass spectrometry, Fourier transform mass spectrometry is develo** into an important analytical tool capable of ion storage, manipulation and remarkable resolution and sen...

    Cliffton B. Jacoby, Christopher L. Holliman… in Mass Spectrometry in the Biological Scienc… (1992)