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  1. No Access

    Article

    RTG-TOF, a rainbow trout (Oncorhynchus mykiss) cell line with an inducible gene expression system

    Jason W. Holland, Christopher J. Secombes in In Vitro Cellular & Developmental Biology … (2022)

  2. Article

    Open Access

    High-throughput proteomic profiling of the fish liver following bacterial infection

    High-throughput proteomics was used to determine the role of the fish liver in defense responses to bacterial infection. This was done using a rainbow trout (Oncorhynchus mykiss) model following infection with Ae...

    Dwight R Causey, Moritz A N Pohl, David A Stead, Samuel A M Martin in BMC Genomics (2018)

  3. Article

    Open Access

    Differential responses of the gut transcriptome to plant protein diets in farmed Atlantic salmon

    The potential for alternative plant protein sources to replace limited marine ingredients in fish feeds is important for the future of the fish farming industry. However, plant ingredients in fish feeds contai...

    Elżbieta Król, Alex Douglas, Douglas R. Tocher, Viv O. Crampton in BMC Genomics (2016)

  4. Article

    Open Access

    Inflammatory responses in primary muscle cell cultures in Atlantic salmon (Salmo salar)

    The relationship between fish health and muscle growth is critical for continued expansion of the aquaculture industry. The effect of immune stimulation on the expression of genes related to the energy balance...

    Nicholas J Pooley, Luca Tacchi, Christopher J Secombes, Samuel AM Martin in BMC Genomics (2013)

  5. Article

    Open Access

    Transcriptomic and physiological responses to fishmeal substitution with plant proteins in formulated feed in farmed Atlantic salmon (Salmo salar)

    Aquaculture of piscivorous fish is in continual expansion resulting in a global requirement to reduce the dependence on wild caught fish for generation of fishmeal and fish oil. Plant proteins represent a suit...

    Luca Tacchi, Christopher J Secombes, Ralph Bickerdike, Michael A Adler in BMC Genomics (2012)

  6. Article

    Open Access

    Genomic organisation analysis of novel immunoglobulin-like transcripts in Atlantic salmon (Salmo salar) reveals a tightly clustered and multigene family

    Several novel immunoglobulin-like transcripts (NILTs) which have previously been identified in the salmonid species rainbow trout (Oncorhynchus mykiss) contain either one or two extracellular Ig domains of the V-...

    Anders E Østergaard, Krzysztof P Lubieniecki, Samuel AM Martin in BMC Genomics (2010)

  7. Article

    Open Access

    Starvation alters the liver transcriptome of the innate immune response in Atlantic salmon (Salmo salar)

    The immune response is an energy demanding process, which has effects in many physiological pathways in the body including protein and lipid metabolism. During an inflammatory response the liver is required to...

    Samuel AM Martin, Alex Douglas, Dominic F Houlihan, Christopher J Secombes in BMC Genomics (2010)

  8. Article

    Open Access

    Directional responses following recombinant cytokine stimulation of rainbow trout (Oncorhynchus mykiss) RTS-11 macrophage cells as revealed by transcriptome profiling

    The early stages of the immune response are regulated by key cytokines including both interleukin 1β (IL-1β) and interferon-γ (IFN-γ) which stimulate panels of responsive genes via conserved signal transductio...

    Samuel AM Martin, Jun Zou, Dominic F Houlihan, Christopher J Secombes in BMC Genomics (2007)

  9. No Access

    Chapter

    Fish Cytokine Genes

    Relatively few cytokine and cytokine receptor genes had been sequenced in fish prior to EST and genome studies. The number of sequences is rapidly increasing and demonstrates the complexity of the cytokine net...

    Christopher J. Secombes, Jun Zou, Bertrand Collet in Aquatic Genomics (2003)