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  1. Article

    Open Access

    Starvation alters the liver transcriptome of the innate immune response in Atlantic salmon (Salmo salar)

    The immune response is an energy demanding process, which has effects in many physiological pathways in the body including protein and lipid metabolism. During an inflammatory response the liver is required to...

    Samuel AM Martin, Alex Douglas, Dominic F Houlihan, Christopher J Secombes in BMC Genomics (2010)

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  2. Article

    Open Access

    Directional responses following recombinant cytokine stimulation of rainbow trout (Oncorhynchus mykiss) RTS-11 macrophage cells as revealed by transcriptome profiling

    The early stages of the immune response are regulated by key cytokines including both interleukin 1β (IL-1β) and interferon-γ (IFN-γ) which stimulate panels of responsive genes via conserved signal transductio...

    Samuel AM Martin, Jun Zou, Dominic F Houlihan, Christopher J Secombes in BMC Genomics (2007)

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  3. No Access

    Article

    Minimising aerobic respiratory demands could form the basis to sub-lethal copper tolerance by rainbow trout gill epithelial cells in vitro

    Mechanisms of Cu tolerance were investigated in respiratory epithelial cell cultures, from rainbow trout gills, by studying O2 consumption and protein synthesis rates, intracellular Na concentration and TER. The ...

    Richard W. Smith, Maria Jönsson, Dominic F. Houlihan… in Fish Physiology and Biochemistry (2001)

  4. No Access

    Article

    Immune parameters of plaice, Pleuronectes platessa, L. along a sewage sludge gradient in the Firth of Clyde, Scotland

    Plaice were caught at five stations varying in distance from the sewage sludge dum** site at Garroch Head, in the Firth of Clyde, Scotland and a number of physical and immunological parameters monitored. Sig...

    Christopher J. Secombes, Ann White, Thelma C. Fletcher, Ronald Stagg… in Ecotoxicology (1995)

  5. No Access

    Article

    The energetic cost of protein synthesis in isolated hepatocytes of rainbow trout (Oncorhynchus mykiss)

    To establish the energetic cost of protein synthesis, isolated trout hepatocytes were used to measure protein synthesis and respiration simultaneously at a variety of temperatures. The presence of bovine serum...

    Marinus C. Pannevis, Dominic F. Houlihan in Journal of Comparative Physiology B (1992)

  6. No Access

    Article

    Protein synthesis in trout liver is stimulated by both feeding and fasting

    The response of protein synthesis in the liver of the rainbow trout to feeding and fasting was investigated in 3 experiments. In the first experiment, the fractional rate of protein synthesis (k ...

    D. Nelson McMillan, Dominic F. Houlihan in Fish Physiology and Biochemistry (1992)