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Article
Open AccessBiologic Abatement and Capturing Kids’ Outcomes and Flare Frequency in Juvenile Spondyloarthritis (BACK-OFF JSpA): study protocol for a randomized pragmatic trial
The effectiveness of biologic therapies, primarily tumor necrosis factor inhibitors (TNFi), for children with spondyloarthritis (SpA) has made inactive disease a realistic patient outcome. However, biologic th...
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Article
Open AccessThe Gross Developmental Potential (GDP2): a new approach for measuring human potential and wellbeing
Many factors influence the health and well-being of children and the adults they will become. Yet there are significant gaps in how trajectories of healthy development are measured, how the potential for leadi...
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Article
Antibiotics prior to age 2 years have limited association with preschool growth trajectory
Prior studies of early antibiotic use and growth have shown mixed results, primarily on cross-sectional outcomes. This study examined the effect of oral antibiotics before age 24 months on growth trajectory at...
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Article
Open AccessClinical data for paediatric research: the Swiss approach
Continuous improvement of health and healthcare system is hampered by inefficient processes of generating new evidence, particularly in the case of rare diseases and paediatrics. Currently, most evidence is ge...
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Article
Are there birth cohort effects in disparities in child obesity by maternal education?
Children belonging to the same birth cohort (i.e., born in the same year) experience shared exposure to a common obesity-related milieu during the critical early years of development—e.g., secular beliefs and ...
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Article
Privacy-protecting multivariable-adjusted distributed regression analysis for multi-center pediatric study
Privacy-protecting analytic approaches without centralized pooling of individual-level data, such as distributed regression, are particularly important for vulnerable populations, such as children, but these m...
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Maternal antibiotic use during pregnancy and childhood obesity at age 5 years
The benefits of antibiotic treatment during pregnancy are immediate, but there may be long-term risks to the develo** child. Prior studies show an association between early life antibiotics and obesity, but ...
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Open AccessDevelo** a framework for the ethical design and conduct of pragmatic trials in healthcare: a mixed methods research protocol
There is a widely recognized need for more pragmatic trials that evaluate interventions in real-world settings to inform decision-making by patients, providers, and health system leaders. Increasing availabili...
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Open AccessThe impact of primary care on emergency department presentation and hospital admission with pneumonia: a case–control study of preschool-aged children
In children, community-acquired pneumonia is a frequent cause of emergency department (ED) presentation and hospital admission. Quality primary care may prevent some of these hospital visits.
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Parental Preferences for Primary and Specialty Care Collaboration in the Management of Teens with Congenital Heart Disease
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A Severity of Illness Index and Health-Related Quality of Life for Teens with Congenital Heart Disease