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Open AccessSpectrum of severity of multisystem inflammatory syndrome in children: an EHR-based cohort study from the RECOVER program
Multi-system inflammatory syndrome in children (MIS-C) is a severe post-acute sequela of SARS-CoV-2 infection in children, and there is a critical need to unfold its highly heterogeneous disease patterns. Our ...
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Article
Antibiotics prior to age 2 years have limited association with preschool growth trajectory
Prior studies of early antibiotic use and growth have shown mixed results, primarily on cross-sectional outcomes. This study examined the effect of oral antibiotics before age 24 months on growth trajectory at...
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Article
Privacy-protecting multivariable-adjusted distributed regression analysis for multi-center pediatric study
Privacy-protecting analytic approaches without centralized pooling of individual-level data, such as distributed regression, are particularly important for vulnerable populations, such as children, but these m...
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Article
Maternal antibiotic use during pregnancy and childhood obesity at age 5 years
The benefits of antibiotic treatment during pregnancy are immediate, but there may be long-term risks to the develo** child. Prior studies show an association between early life antibiotics and obesity, but ...
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Article
Open AccessGenomic analysis of early murine mammary gland development using novel probe-level algorithms
We describe a novel algorithm (ChipStat) for detecting gene-expression changes utilizing probe-level comparisons of replicate Affymetrix oligonucleotide microarray data. A combined detection approach is shown ...
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A gene belonging to the Sm family of snRNP core proteins maps within the mouse MHC
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Cloning a balanced translocation associated with DiGeorge syndrome and identification of a disrupted candidate gene
DiGeorge syndrome (DGS), a developmental defect, is characterized by cardiac defects and aplasia or hypoplasia of the thymus and parathyroid glands. DGS has been associated with visible chromosomal abnormaliti...
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Article
The Lowe's oculocerebrorenal syndrome gene encodes a protein highly homologous to inositol polyphosphate-5-phosphatase
LOWE'S oculocerebrorenal syndrome1–3 (OCRL) is a human X-linked developmental disorder of unknown pathogenesis4–8 and has a pleiotropic phenotype affecting the lens, brain and kidneys. The OCRL locus has been map...