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  1. Article

    Open Access

    Preoperative three-dimensional lung volumetry predicts respiratory complications in patients undergoing major liver resection for colorectal metastases

    Colorectal liver metastases (CRLM) are the predominant factor limiting survival in patients with colorectal cancer and liver resection with complete tumor removal is the best treatment option for these patient...

    Suzan Elmaagacli, Christoph Thiele, Franziska Meister, Philipp Menne… in Scientific Reports (2024)

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  2. Article

    Open Access

    Generation of immune cell containing adipose organoids for in vitro analysis of immune metabolism

    Adipose tissue is an organized endocrine organ with important metabolic and immunological functions and immune cell-adipocyte crosstalk is known to drive various disease pathologies. Suitable 3D adipose tissue...

    Jacqueline Taylor, Julia Sellin, Lars Kuerschner, Lennart Krähl… in Scientific Reports (2020)

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  3. No Access

    Article

    Molecular recognition of a single sphingolipid species by a protein’s transmembrane domain

    A sphingomyelin-binding motif is identified in the membrane-spanning domain of p24, a COPI machinery protein.

    F.-Xabier Contreras, Andreas M. Ernst, Per Haberkant, Patrik Björkholm… in Nature (2012)

  4. No Access

    Article

    Lipoprotein particles are required for Hedgehog and Wingless signalling

    Wnt and Hedgehog family proteins are secreted signalling molecules (morphogens) that act at both long and short range to control growth and patterning during development. Both proteins are covalently modified ...

    Daniela Panáková, Hein Sprong, Eric Marois, Christoph Thiele, Suzanne Eaton in Nature (2005)

  5. No Access

    Article

    Endophilin I mediates synaptic vesicle formation by transfer of arachidonate to lysophosphatidic acid

    Endophilin I is a presynaptic protein of unknown function that binds to dynamin, a GTPase that is implicated in endocytosis and recycling of synaptic vesicles. Here we show that endophilin I is essential for t...

    Anne Schmidt, Michael Wolde, Christoph Thiele, Werner Fest, Hartmut Kratzin… in Nature (1999)