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  1. No Access

    Article

    An RNA vaccine drives immunity in checkpoint-inhibitor-treated melanoma

    Treating patients who have cancer with vaccines that stimulate a targeted immune response is conceptually appealing, but cancer vaccine trials have not been successful in late-stage patients with treatment-ref...

    Ugur Sahin, Petra Oehm, Evelyna Derhovanessian, Robert A. Jabulowsky… in Nature (2020)

  2. Article

    Publisher Correction: Actively personalized vaccination trial for newly diagnosed glioblastoma

    The additional author support information was erroneously omitted from the Supplementary Information. This has been corrected online.

    Norbert Hilf, Sabrina Kuttruff-Coqui, Katrin Frenzel, Valesca Bukur… in Nature (2019)

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  3. No Access

    Article

    Actively personalized vaccination trial for newly diagnosed glioblastoma

    Patients with glioblastoma currently do not sufficiently benefit from recent breakthroughs in cancer treatment that use checkpoint inhibitors1,2. For treatments using checkpoint inhibitors to be successful, a hig...

    Norbert Hilf, Sabrina Kuttruff-Coqui, Katrin Frenzel, Valesca Bukur… in Nature (2019)

  4. No Access

    Article

    Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer

    The authors report the first-in-human application of personalized neo-antigen RNA vaccines in patients with melanoma.

    Ugur Sahin, Evelyna Derhovanessian, Matthias Miller, Björn-Philipp Kloke… in Nature (2017)

  5. No Access

    Article

    Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy

    The development of a nanoparticle RNA vaccine is reported that preferentially targets dendritic cells after systemic administration, and is shown to provide durable interferon-α-dependent antigen-specific immu...

    Lena M. Kranz, Mustafa Diken, Heinrich Haas, Sebastian Kreiter, Carmen Loquai… in Nature (2016)

  6. Article

    Erratum: Mutant MHC class II epitopes drive therapeutic immune responses to cancer

    Nature 520, 692–696 (2015); doi:10.1038/nature14426 In this Letter, there were minor formatting errors in the poly‐neo‐epitope RNA in Fig. 3a, which occurred during the production process; this figure has been...

    Sebastian Kreiter, Mathias Vormehr, Niels van de Roemer, Mustafa Diken… in Nature (2015)

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  7. No Access

    Article

    Mutant MHC class II epitopes drive therapeutic immune responses to cancer

    The authors show that a large fraction of tumour mutations is immunogenic and predominantly recognized by CD4+ T cells; they use these data to design synthetic messenger-RNA-based vaccines specific against tumour...

    Sebastian Kreiter, Mathias Vormehr, Niels van de Roemer, Mustafa Diken… in Nature (2015)

  8. Article

    Austria: investigation likely to have serious consequences

    Guenther Bonn, Christiane Druml, Gabriele Fischer, Christoph Huber, Stephan Laske… in Nature (2008)

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