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  1. No Access

    Article

    PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing

    The sensing of microbial genetic material by leukocytes often elicits beneficial pro-inflammatory cytokines, but dysregulated responses can cause severe pathogenesis. Genome-wide association studies have linke...

    Amanda L. Gavin, Deli Huang, Christoph Huber, Annica Mårtensson… in Nature Immunology (2018)

  2. No Access

    Protocol

    The European Regulatory Environment of RNA-Based Vaccines

    A variety of different mRNA-based drugs are currently in development. This became possible, since major breakthroughs in RNA research during the last decades allowed impressive improvements of translation, sta...

    Thomas Hinz, Kajo Kallen, Cedrik M. Britten, Bruno Flamion, Ulrich Granzer… in RNA Vaccines (2017)

  3. No Access

    Article

    The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow

    B cells arise via a precise developmental pathway. Goodnow and Beutler report that mice bearing mutations in Atp11c, which encodes a phosphatidylserine 'flippase', have defective B cell generation in the adult bo...

    Owen M Siggs, Carrie N Arnold, Christoph Huber, Elaine Pirie, Yu **a… in Nature Immunology (2011)

  4. No Access

    Article

    Dissection and molecular analysis of alloreactive CD8+ T cell responses in allogeneic haematopoietic stem cell transplantation

    We applied a cDNA expression screening procedure with cryopreserved non-clonal CD8+ T cell populations (Lennerz et al., Proc. Natl. Acad. Sci. USA 102:16013-8, 2005) to the identification of candidate antigens...

    Catherine Wölfel, Volker Lennerz, Eva Lindemann… in Cancer Immunology, Immunotherapy (2008)

  5. No Access

    Article

    Simultaneous ex vivo quantification of antigen-specific CD4+ and CD8+ T cell responses using in vitro transcribed RNA

    Assessment of antigen-specific T-cell responses has been greatly facilitated by development of ELISPOT and intracellular cytokine flow cytometry (CFC) assays. The use of autologous antigen presenting cells tra...

    Sebastian Kreiter, Thorsten Konrad, Martina Sester… in Cancer Immunology, Immunotherapy (2007)

  6. No Access

    Article

    Redirection of T cells by delivering a transgenic mouse-derived MDM2 tumor antigen-specific TCR and its humanized derivative is governed by the CD8 coreceptor and affects natural human TCR expression

    Retroviral transfer of T cell antigen receptor (TCR) genes selected by circumventing tolerance to broad tumor- and leukemia-associated antigens in human leukocyte antigen (HLA)-A*0201 (A2.1) transgenic (Tg) mice ...

    Ralf-Holger Voss, Jürgen Kuball, Renate Engel, Philipe Guillaume… in Immunologic Research (2006)

  7. No Access

    Article

    A phase I vaccination study with tyrosinase in patients with stage II melanoma using recombinant modified vaccinia virus Ankara (MVA-hTyr)

    A significant percentage of patients with stage II melanomas suffer a relapse after surgery and therefore need the development of adjuvant therapies. In the study reported here, safety and immunological respon...

    Ralf G. Meyer, Cedrik M. Britten, Ulrike Siepmann… in Cancer Immunology, Immunotherapy (2005)

  8. No Access

    Article

    Subcutaneous injection of interleukin 12 induces systemic inflammatory responses in humans: implications for the use of IL-12 as vaccine adjuvant

    Interleukin 12 (IL-12) is a cytokine with important regulatory functions bridging innate and adaptive immunity. It has been proposed as an immune adjuvant for vaccination therapy of infectious diseases and mal...

    Johanna E. A. Portielje, Wim H. J. Kruit… in Cancer Immunology, Immunotherapy (2005)

  9. No Access

    Article

    Cloning and functional analyses of the mouse tapasin promoter

    The expression of tapasin is critical for an optimized MHC class I assembly and stable MHC class I surface expression. Thus, impaired MHC class I antigen expression of tumors can be attributable to tapasin dow...

    Felix Herrmann, John Trowsdale, Christoph Huber, Barbara Seliger in Immunogenetics (2003)

  10. No Access

    Article

    Circumventing tolerance to a human MDM2-derived tumor antigen by TCR gene transfer

    We identified a tumor-associated cytotoxic T lymphocyte (CTL) epitope derived from the widely expressed human MDM2 oncoprotein and were able to bypass self-tolerance to this tumor antigen in HLA-A*0201 (A2.1) tra...

    Thomas Stanislawski, Ralf-Holger Voss, Carina Lotz, Elena Sadovnikova… in Nature Immunology (2001)

  11. No Access

    Article

    Induction of accessory cell function of human alveolar macrophages by inhalation of human natural interleukin-2

     Accessory function allows antigen-presenting cells to produce sufficient secondary signals for optimum T cell proliferation and interleukin-2 (IL-2) production. Alveolar macrophages are inferior accessory cel...

    Gernot Zissel, Walter E. Aulitzky, J. Lorenz… in Cancer Immunology, Immunotherapy (1996)

  12. No Access

    Article

    Restimulation in secondary MLC by a non-D-locus determinant within the MHC

    By testing a family in which one offspring had inherited a chromosome including a recombination between theHLA-B andD loci, we sought to obtain some insight into whether determinants other than those atHLA-D are ...

    Karen S. Zier, Hans Grosse-Wilde, Christoph Huber, Herbert Braunsteiner… in Immunogenetics (1978)