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Article
Impact of sedentary behavior on large artery structure and function in children and adolescents: a systematic review
Sedentary behavior contributes to increased atherosclerotic risk in adults. Whether or not this can be extended to pediatric populations is unclear. This systematic review assessed associations of sedentary be...
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Article
Open AccessCa2+ mobilization-dependent reduction of the endoplasmic reticulum lumen is due to influx of cytosolic glutathione
The lumen of the endoplasmic reticulum (ER) acts as a cellular Ca2+ store and a site for oxidative protein folding, which is controlled by the reduced glutathione (GSH) and glutathione-disulfide (GSSG) redox pair...
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Article
Open AccessAntibiotic prophylaxis in transurethral resection of bladder tumours: study protocol for a systematic review and meta-analysis
The necessity of antibiotic prophylaxis for postoperative urinary tract infections (UTIs) after transurethral resection of bladder tumours is controversial. This potentially leads to the overuse of antibiotic ...
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Article
Open AccessMethodological approaches for conducting follow-up research with clinical trial participants: a sco** review and expert interviews
Evidence-based establishment and implementation of best principles, laws and ordinances that regulate clinical research depend on the consultation and involvement of trial participants. Yet, guidance on method...
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Article
Open AccessPrognostic factors for the occurrence of post-operative shoulder stiffness after arthroscopic rotator cuff repair: a systematic review
Post-operative shoulder stiffness (POSS) is one of the most frequent complications after arthroscopic rotator cuff repair (ARCR). Factors specifying clinical prediction models for the occurrence of POSS should...
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Article
Open AccessThe Metabolic Signature of Cardiorespiratory Fitness: A Systematic Review
Cardiorespiratory fitness (CRF) is a potent health marker, the improvement of which is associated with a reduced incidence of non-communicable diseases and all-cause mortality. Identifying metabolic signatures...
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Article
Open AccessPredicting neurological outcome in adult patients with cardiac arrest: systematic review and meta-analysis of prediction model performance
This work aims to assess the performance of two post-arrest (out-of-hospital cardiac arrest, OHCA, and cardiac arrest hospital prognosis, CAHP) and one pre-arrest (good outcome following attempted resuscitatio...
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Article
Open AccessMultidimensional versus unidimensional pain scales for the assessment of analgesic requirement in the emergency department: a systematic review
Pain is a multidimensional experience, potentially rendering unidimensional pain scales inappropriate for assessment. Prior research highlighted their inadequacy as reliable indicators of analgesic requirement...
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Article
Open AccessEffects of exercise training on cardiac output in subjects with heart failure with preserved ejection fraction (HFpEF) — a protocol for a systematic review and meta-analysis
Patients with heart failure with preserved ejection fraction (HFpEF) commonly experience exercise intolerance, resulting in reduced cardiorespiratory fitness. This is characterised by a decreased maximal oxyge...