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Article

Ca²⁺ mobilization-dependent reduction of the endoplasmic reticulum lumen is due to influx of cytosolic glutathione

The lumen of the endoplasmic reticulum (ER) acts as a cellular Ca²⁺ store and a site for oxidative protein folding, which is controlled by the reduced glutathione (GSH) and glutathione-disulfide (GSSG) redox pair...

Beáta Lizák, Julia Birk, Melinda Zana, Gergely Kosztyi, Denise V. Kratschmar… in BMC Biology (2020)