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Article
Open AccessAuthor Correction: Droplet microfluidics for the highly controlled synthesis of branched gold nanoparticles
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Article
Open AccessImproving the efficiency and effectiveness of an industrial SARS-CoV-2 diagnostic facility
On 11th March 2020, the UK government announced plans for the scaling of COVID-19 testing, and on 27th March 2020 it was announced that a new alliance of private sector and academic collaborative laboratories ...
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Article
Open AccessInhibiting Mycobacterium tuberculosis CoaBC by targeting an allosteric site
Coenzyme A (CoA) is a fundamental co-factor for all life, involved in numerous metabolic pathways and cellular processes, and its biosynthetic pathway has raised substantial interest as a drug target against m...
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Article
Open AccessUnexpected stability of aqueous dispersions of raspberry-like colloids
Aqueous colloidal suspensions, both man-made and natural, are part of our everyday life. The applicability of colloidal suspensions, however, is limited by the range of conditions over which they are stable. H...
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Article
Open AccessDroplet microfluidics for the highly controlled synthesis of branched gold nanoparticles
The synthesis of anisotropic metallic nanoparticles (NPs) has been a field of intense and challenging research in the past decade. In this communication, we report on the reproducible and highly controllable s...
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Article
Open AccessCorrection: Corrigendum: Surface mediated cooperative interactions of drugs enhance mechanical forces for antibiotic action
Scientific Reports 7:Article number: 41206; published online: 03 February 2017; updated: 23 March 2017 This Article contains errors. An additional affiliation for Samadhan B. Patil was omitted. The correct aff...
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Article
Open AccessSurface mediated cooperative interactions of drugs enhance mechanical forces for antibiotic action
The alarming increase of pathogenic bacteria that are resistant to multiple antibiotics is now recognized as a major health issue fuelling demand for new drugs. Bacterial resistance is often caused by molecula...
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Protocol
Antagonists of the miRNA-Argonaute 2 Protein Complex: Anti-miR-AGOs
microRNAs (miRNAs) have been identified as high-value drug targets. A widely applied strategy in miRNA inhibition is the use of antisense agents. However, it has been shown that oligonucleotides are poorly cel...
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Article
Small molecules, big targets: drug discovery faces the protein–protein interaction challenge
Protein–protein interactions (PPIs) are increasingly being targeted by drug discovery groups, and there exists great scope for therapeutic modulation of this t...
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Article
Open AccessStructural characterization of CYP144A1 – a cytochrome P450 enzyme expressed from alternative transcripts in Mycobacterium tuberculosis
Mycobacterium tuberculosis (Mtb) causes the disease tuberculosis (TB). The virulent Mtb H37Rv strain encodes 20 cytochrome P450 (CYP) enzymes, many of which are implicated in Mtb survival and pathogenicity in the...
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Article
Interfacial assembly of dendritic microcapsules with host–guest chemistry
The self-assembly of nanoscale materials to form hierarchically ordered structures promises new opportunities in drug delivery, as well as magnetic materials and devices. Herein, we report a simple means to pr...
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Article
Evolution of enzyme catalysts caged in biomimetic gel-shell beads
Natural evolution relies on the improvement of biological entities by rounds of diversification and selection. In the laboratory, directed evolution has emerged as a powerful tool for the development of new an...
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Article
Surface-stress sensors for rapid and ultrasensitive detection of active free drugs in human serum
There is a growing appreciation that mechanical signals can be as important as chemical and electrical signals in biology. To include such signals in a systems biology description for understanding pathobiolog...
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Article
A three-stage biophysical screening cascade for fragment-based drug discovery
This protocol describes the screening of a library of low-molecular-weight compounds (fragments) using a series of biophysical ligand-binding assays. Fragment-based drug discovery (FBDD) has emerged as a succe...
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Article
Open AccessTri-partite complex for axonal transport drug delivery achieves pharmacological effect
Targeted delivery of pharmaceutical agents into selected populations of CNS (Central Nervous System) neurons is an extremely compelling goal. Currently, systemic methods are generally used for delivery of pain...
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Chapter and Conference Paper
Fragment-Based Drug Discovery in Academia: Experiences From a Tuberculosis Programme
The problems associated with neglected diseases are often compounded by increasing incidence of antibiotic resistance. Patient negligence and abuse of antibiotics has lead to explosive growth in cases of tuber...
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Article
Nanomechanical detection of antibiotic–mucopeptide binding in a model for superbug drug resistance
The alarming growth of the antibiotic-resistant superbugs methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE) is driving the development of new technologies to investiga...
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Article
Towards engineering increased pantothenate (vitamin B5) levels in plants
Pantothenate (vitamin B5) is the precursor of the 4′-phosphopantetheine moiety of coenzyme A and acyl-carrier protein. It is made by plants and microorganisms de novo, but is a dietary requirement for animals. Th...
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Chapter and Conference Paper
Cell Based Biological Assay Using Microfluidics
A microfluidic device has been designed to measure and manipulate microdroplets, in which protein expression is induced in single cells. The device exploits the permeation of water through poly (dimethylsiloxa...
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Article
High-throughput crystallography for lead discovery in drug design
Knowledge of the three-dimensional structures of target proteins provides a starting point for structure-based approaches to drug design by defining the topogr...
