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  1. Article

    Open Access

    Aberrant expression of a stabilized β-catenin mutant in keratocytes inhibits mouse corneal epithelial stratification

    We previously reported that genetic deletion of β-catenin in mouse corneal keratocytes resulted in precocious corneal epithelial stratification. In this study, to strengthen the notion that corneal keratocyte-...

    Lingling Zhang, Yen-Chiao Wang, Yuka Okada, Suohui Zhang… in Scientific Reports (2019)

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  2. Article

    Open Access

    Impaired healing of cornea incision injury in a TRPV1-deficient mouse

    The present study attempts to elucidate the role of TRPV1 cation channel receptor on primary repair in an incision-wounded mouse cornea in vivo. Previous study revealed that blocking TRPV1 suppressed myofibrob...

    Yuka Nidegawa-Saitoh, Takayoshi Sumioka, Yuka Okada… in Cell and Tissue Research (2018)

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  3. Article

    Open Access

    Wakayama symposium: role of canonical Notch signaling in conjucntival goblet cell differentiation and dry eye syndrome

    This review summarizes a recent finding regarding the intrinsic canonical Notch signaling pathway in regulating normal ocular surface morphogenesis and its role in the pathogenesis of goblet cell deficiency-as...

    Chia-Yang Liu in BMC Ophthalmology (2015)

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  4. No Access

    Article

    Ocular Delivery of pRNA Nanoparticles: Distribution and Clearance After Subconjunctival Injection

    RNA nanoparticles derived from the three-way junction (3WJ) of the pRNA of bacteriophage phi29 DNA packaging motor were previously found to be thermodynamically stable. As the nanoparticles could have potentia...

    Liang Feng, S. Kevin Li, Hongshan Liu, Chia-Yang Liu… in Pharmaceutical Research (2014)

  5. No Access

    Protocol

    Lumican Promotes Corneal Epithelial Wound Healing

    Lumican regulates collagenous matrix assembly as a keratan sulfate proteoglycan in the cornea and is also present in the connective tissues of other organs and embryonic corneal stroma as a glycoprotein. In no...

    Chia-Yang Liu, Winston Whei-Yang Kao in Proteoglycans (2012)

  6. No Access

    Article

    Corneal morphogenesis during development and wound healing

    Winston W.-Y. Kao, Chia-Yang Liu in Japanese Journal of Ophthalmology (2010)

  7. No Access

    Chapter and Conference Paper

    Evaluating Emotive Character Animations Created with Procedural Animation

    How to create effective body animations for virtual agents with emotions remains the state of the art for human animators and a great challenge for computer scientists. In this paper, we propose to use a model...

    Yueh-Hung Lin, Chia-Yang Liu, Hung-Wei Lee, Shwu-Lih Huang… in Intelligent Virtual Agents (2009)

  8. No Access

    Chapter and Conference Paper

    Verification of Expressiveness of Procedural Parameters for Generating Emotional Motions

    Body movements are crucial for emotion expression of a virtual agent. However, the perception of expressiveness of an animation has always been a subjective matter. Research in psychology has asked professiona...

    Yueh-Hung Lin, Chia-Yang Liu, Hung-Wei Lee, Shwu-Lih Huang… in Intelligent Virtual Agents (2008)

  9. No Access

    Article

    Roles of lumican and keratocan on corneal transparency

    Lumican and keratocan are members of the small leucine-rich proteoglycan (SLRP) family, and are the major keratan sulfate (KS) proteoglycans in corneal stroma. Both lumican and keratocan are essential for norm...

    Winston W.-Y. Kao, Chia-Yang Liu in Glycoconjugate Journal (2002)