90 Result(s)
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Chenxi **e
Cell Biology
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Article
RUNX3 exerts tumor-suppressive role through inhibiting EXOSC4 expression
Breast cancer severely affects women health. 70% of breast cancer are estrogen receptor positive. Breast cancer stem cells are a group of tumor with plasticity, causing tumor relapse and metastasis. RUNX3 is a...
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Streptomyces camelliae sp. nov., isolated from rhizosphere soil of Camellia oleifera Abel
A novel actinobacterium strain, designated HUAS 2-6 T, was isolated from the rhizosphere soil of Camellia oleifera Abel collected from Taoyuan County, Northwestern Hunan Province, South China. This strain was sub...
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Open AccessA novel disulfide death-related genes prognostic signature identifies the role of IPO4 in glioma progression
“Disulfide death,” a form of cellular demise, is triggered by the abnormal accumulation of intracellular disulfides under conditions of glucose deprivation. However, its role in the prognosis of glioma remains...
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Open AccessUnraveling ferroptosis in osteogenic lineages: implications for dysregulated bone remodeling during periodontitis progression
Periodontitis is a highly prevalent disease characterized by inflammation and destruction of tooth-supporting tissues that leads to tooth loss in extreme situations. Elucidating the underlying mechanisms of pe...
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Open AccessFetal growth restriction exhibits various mTOR signaling in different regions of mouse placentas with altered lipid metabolism
Fetal growth restriction (FGR) is a common complication of pregnancy and can have significant impact on obstetric and neonatal outcomes. Increasing evidence has shown that the inhibited mechanistic target of r...
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Open AccessHigh estrogen during ovarian stimulation induced loss of maternal imprinted methylation that is essential for placental development via overexpression of TET2 in mouse oocytes
Ovarian stimulation (OS) during assisted reproductive technology (ART) appears to be an independent factor influencing the risk of low birth weight (LBW). Previous studies identified the association between LB...
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VEGFR affects miR-3200-3p-mediated regulatory T cell senescence in tumour-derived exosomes in non-small cell lung cancer
Numerous studies have demonstrated that regulatory T (Treg) cells play an important role in the tumour microenvironment (TME). The aim of this study was to investigate whether VEGFR2 affects the expression of ...
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Open AccessFunctional role of Ash2l in oxLDL induced endothelial dysfunction and atherosclerosis
Endothelial injury and dysfunction in the artery wall fuel the process of atherosclerosis. As a key epigenetic regulator, Ash2l (Absent, small, or homeotic-Like 2) is involved in regulating vascular injury and...
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Open AccessLOXL1 promotes tumor cell malignancy and restricts CD8 + T cell infiltration in colorectal cancer
Colorectal cancer (CRC) is a leading cause of cancer mortality globally. Lymph node metastasis and immunosuppression are main factors of poor prognosis in CRC patients. Lysyl oxidase like 1 (LOXL1), part of th...
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Open AccessNeddylation is a novel therapeutic target for lupus by regulating double negative T cell homeostasis
Systemic lupus erythematosus (SLE), a severe autoimmune disorder, is characterized by systemic inflammatory response, autoantibody accumulation and damage to organs. The dysregulation of double-negative (DN) T...
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Open AccessJosephin domain containing 2 (JOSD2) promotes lung cancer by inhibiting LKB1 (Liver kinase B1) activity
Non-small cell lung cancer (NSCLC) ranks as one of the leading causes of cancer-related deaths worldwide. Despite the prominence and effectiveness of kinase-target therapies in NSCLC treatment, these drugs are...
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Respiratory Effects under Air Humidity Stress in Fruit Bodies of Auricularia heimuer
In order to study the environmental adaptation mechanism to air humidity stress for fruit bodies of Auricularia heimuer, we studied its respiratory effects. A. heimuer was cultivated in a greenhouse, and samples ...
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Impeding DNA Polymerase β Activity by Oleic Acid to Inhibit Base Excision Repair and Induce Mitochondrial Dysfunction in Hepatic Cells
Free fatty acids (FFAs) hepatic accumulation and the resulting oxidative stress contribute to several chronic liver diseases including nonalcoholic steatohepatitis. However, the underlying pathological mechani...
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Open AccessIGF2BP2-meidated m6A modification of CSF2 reprograms MSC to promote gastric cancer progression
The interaction between tumor cells and stromal cells within the tumor microenvironment plays a critical role in cancer progression. Mesenchymal stem cells (MSCs) are important tumor stromal cells that exhibit...
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Article
The oxidative damage induced by lead sulfide nanoparticles in rat kidney
Lead sulfide nanoparticles (PbS NPs) are an important semiconductor material, which has been widely used in light-emitting diodes (LEDs), biological fluorescent probes, biological in vivo imaging, infrared det...
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Open AccessMultidimensional quantitative phenotypic and molecular analysis reveals neomorphic behaviors of p53 missense mutants
Mutations in the TP53 tumor suppressor gene occur in >80% of the triple-negative or basal-like breast cancer. To test whether neomorphic functions of specific TP53 missense mutations contribute to phenotypic hete...
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The Temporal and Spatial Changes of Autophagy and PI3K Isoforms in Different Neural Cells After Hypoxia/Reoxygenation Injury
There are limited therapeutic options for patient with traumatic spinal cord injury (SCI). Phosphoinositide 3-kinase family (PI3Ks) are the key molecules for regulating cell autophagy, which is a possible way ...
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Open AccessN6-methyladenosine modification of REG1α facilitates colorectal cancer progression via β-catenin/MYC/LDHA axis mediated glycolytic reprogramming
Aerobic glycolysis has been considered as a hallmark of colorectal cancer (CRC). However, the potential functional regulators of glycolysis in CRC remains to be elucidated. In the current study, we found that ...
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Open AccessEIF4A3-mediated circ_0042881 activates the RAS pathway via miR-217/SOS1 axis to facilitate breast cancer progression
Breast cancer (BC) is one of the most frequent cancer-related deaths in women worldwide. Studies have shown the potential impact of circRNAs in multiple human tumorigeneses. Research on the vital signaling pat...
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Open AccessPoly (ADP-ribose) polymerases 16 triggers pathological cardiac hypertrophy via activating IRE1α–sXBP1–GATA4 pathway
Pressure overload-induced pathological cardiac hypertrophy is an independent predecessor of heart failure (HF), which remains the leading cause of worldwide mortality. However, current evidence on the molecula...
