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Article
Open AccessPACS-2 deficiency aggravates tubular injury in diabetic kidney disease by inhibiting ER-phagy
Autophagy of endoplasmic reticulum (ER-phagy) selectively removes damaged ER through autophagy-lysosome pathway, acting as an adaptive mechanism to alleviate ER stress and restore ER homeostasis. However, the ...
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Article
Open Access4-Octyl itaconate attenuates LPS-induced acute kidney injury by activating Nrf2 and inhibiting STAT3 signaling
Septic acute kidney injury (S-AKI) is the leading form of acute kidney failure among hospitalized patients, and the inflammatory response is involved in this process. 4-octyl itaconate (4-OI) is a multi-target...
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Article
Open AccessPACS-2 deficiency in tubular cells aggravates lipid-related kidney injury in diabetic kidney disease
Lipid accumulation in tubular cells plays a key role in diabetic kidney disease (DKD). Targeting lipid metabolism disorders has clinical value in delaying the progression of DKD, but the precise mechanism by w...
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Article
Characterization of seismic information entropy attributes of braided river delta sedimentary microfacies for the upper Shaximiao formation in the Wubaochang area, northeastern Sichuan Basin, China
The Wubaochang structure is located at the edge of the eastern Sichuan structural belt, at the intersection of the Dabashan and eastern Sichuan arcuate fold-and-thrust belts. The tectonic setting is complex an...
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Article
Feature-based Quality Assessment of Middle Cerebral Artery Occlusion Using 18F-Fluorodeoxyglucose Positron Emission Tomography
In animal experiments, ischemic stroke is usually induced through middle cerebral artery occlusion (MCAO), and quality assessment of this procedure is crucial. However, an accurate assessment method based on 1...
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Article
The influence of soil moisture on convective activity: a review
Soil moisture (SM) influences the initiation and development of convective systems and consequently the generation and development of precipitation through land–air interaction. Understanding and identifying t...
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Chapter and Conference Paper
Application of Intelligent Seismic Fracture Identification Technology to Permeability Prediction in Wubaochang Area, Eastern Sichuan
The dense sandstone gas reservoir in the Xuhui section of the Upper Triassic Xujiahe Formation in the northeast of the Sichuan Basin is considerably non-homogeneous. Therefore, the accurate prediction of the d...
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Chapter and Conference Paper
Finite Difference Method for Convection-Diffusion Equation
The convection-diffusion equation is a problem in the field of fluid mechanics. In addition to proving its validity, obvious phenomena of convection and diffusion are also observed. This paper did three numeri...
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Article
Spatial variation of gully development in the loess plateau of China based on the morphological perspective
Gullies characterized by frequent material exchange have profoundly affected the loess landforms evolution in the Loess Plateau of China. Accompanying gully development, various types of gullies have shaped th...
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Article
Open AccessHealth information and health-seeking behaviour in Yemen: perspectives of health leaders, midwives and mothers in two rural areas of Yemen
Humanitarian crises can lead to the rapid change in the health needs of women and newborns, which may give rise to a complex situation that would require various interventions as solutions. This study aimed to...
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Article
Synthesis, Spectroscopic Properties, and Biological Applications of Eight Novel Chlorinated Fluorescent Proteins-labeling Probes
Eight novel chlorinated fluorescent proteins-labeling probes with a linker and reactive group were prepared in 7 steps by the reaction of chlorinated resorcinols with 3, 6-dichloro-4-carboxyphthalic anhydride ...
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Article
Comparison of Intestinal Absorption and Disposition of Structurally Similar Bioactive Flavones in Radix Scutellariae
Radix Scutellariae is a commonly used herbal medicine. Baicalein, wogonin, and oroxylin A are three major bioactive flavones in Radix Scutellariae and share similar chemical structures. The intes...
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Article
Hepatic Metabolism and Disposition of Baicalein via the Coupling of Conjugation Enzymes and Transporters—In Vitro and In Vivo Evidences
Baicalein (Ba) was found to be subject to serious first-pass metabolism after oral administration. We previously revealed the important role of intestine in the low oral bioavailability of Ba. The present stud...
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Article
Investigation on the absorption kinetics of chlorogenic acid in rats by HPLC
Chlorogenic acid (ChA), a major phenolic compound in the Flos Lonicerae, is widely used in the traditional Chinese medicine practice. The purpose of this study is to report the pharmaco-kinetic parameters of C...
