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Article
A single-cell transcriptome atlas of human euploid and aneuploid blastocysts
Aneuploidy is frequently detected in early human embryos as a major cause of early pregnancy failure. However, how aneuploidy affects cellular function remains elusive. Here, we profiled the transcriptomes of ...
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Article
Identification of novel compound heterozygous ZFP36L2 variants implicated in oocyte maturation defects and female infertility
To explore the pathogenesis of oocyte maturation defects.
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Article
Open AccessTesting the generalizability and effectiveness of deep learning models among clinics: sperm detection as a pilot study
Deep learning has been increasingly investigated for assisting clinical in vitro fertilization (IVF). The first technical step in many tasks is to visually detect and locate sperm, oocytes, and embryos in imag...
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Article
Immunological Indicators of Recurrent Pregnancy Loss: A Mendelian Randomization Study
Recurrent pregnancy loss (RPL) is thought to be related to maternal-fetal immune tolerance disorders. Immune monitoring of RPL patients mainly involves two aspects: inflammatory factors and immune cells. Howev...
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Article
Spatial monitoring to reduce COVID-19 vaccine hesitance
Arthur Getis is a pioneer in spatial statistics. His collaboration with Keith Ord has inspired our long-standing collaboration between a geographer and a statistician. Getis often tackled real-world infectious...
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Article
Open AccessSARS-CoV-2 infection is detrimental to pregnancy outcomes after embryo transfer in IVF/ICSI: a prospective cohort study
To explore whether SARS-CoV-2 infection affects the pregnancy outcomes of assisted reproductive techniques (ART).
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Article
Extended application of PGT-M strategies for small pathogenic CNVs
The preimplantation genetic testing for aneuploidy (PGT-A) platform is not currently available for small copy-number variants (CNVs), especially those < 1 Mb. Through strategies used in PGT for monogenic disea...
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Article
Open AccessDetermination of ITS1 haplotypes of Fritillariae Cirrhosae Bulbus by amplicon sequencing
Fritillariae Cirrhosae Bulbus is an antitussive and expectorant Chinese medicinal material derived from the dried bulbs of six Fritillaria species. In the 2015 edition of the Chinese Pharmacopoeia, the polymerase...
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Article
Evaluation of genetic risk of apparently balanced chromosomal rearrangement carriers by breakpoint characterization
To report genetic characteristics and associated risk of chromosomal breaks due to chromosomal rearrangements in large samples.
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Article
Navigation of Knowledge: the Impact of COVID-19 on Pregnancy-a Bibliometric Analysis
Since the outbreak of COVID-19, countries around the world have faced huge economic and social burdens. SARS-COV-2 may exist in nature for a long time due to the diversity of its different variants. Pregnant w...
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Article
Open AccessTranscriptomic profiles reveal the characteristics of oocytes and cumulus cells at GV, MI, and MII in follicles before ovulation
The oocyte and its surrounding cumulus cells (CCs) exist as an inseparable entity. The maturation of the oocyte relies on communication between the oocyte and the surrounding CCs. However, oocyte evaluation is...
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Article
Open AccessExploring the efficacy and beneficial population of preimplantation genetic testing for aneuploidy start from the oocyte retrieval cycle: a real-world study
Preimplantation genetic testing for aneuploidy (PGT-A) is widely used as an embryo selection technique in in vitro fertilization (IVF), but its effectiveness and potential beneficiary populations are unclear.
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Article
Homozygous variants in CDC23 cause female infertility characterized by oocyte maturation defects
Oocyte maturation defects are major phenotypes resulting in female infertility. Although many genetic factors have been found to be responsible for these phenotypes, the underlying pathogenic genes and variant...
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Article
Oxygen concentration from days 1 to 3 after insemination affects the embryo culture quality, cumulative live birth rate, and perinatal outcomes
We aimed to compare embryo development, cumulative live birth rate (CLBR), and perinatal outcomes of embryos cultured in 20% and 5% oxygen from days 1 to 3 after insemination.
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Article
Open AccessLetrozole-stimulated endometrial preparation protocol is a superior alternative to hormone replacement treatment for frozen embryo transfer in women with polycystic ovary syndrome, a cohort study
The current routine endometrial preparation protocol for women with polycystic ovary syndrome (PCOS) is hormone replacement treatment (HRT). Letrozole is rarely used in frozen embryo cycles. Evidence confirmin...
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Article
Conventional IVF is feasible in preimplantation genetic testing for aneuploidy
To investigate the feasibility of the application of conventional in vitro fertilization (cIVF) for couples undergoing preimplantation genetic testing for aneuploidies (PGT-A) with non-male factor infertility.
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Article
Single-Cell RNA-seq Analysis of a Human Embryonic Stem Cell to Endothelial Cell System Based on Transcription Factor Overexpression
Human embryonic stem cell (hESC)-derived endothelial cells (ECs) possess therapeutic potential in many diseases. Cytokine supplementation induction and transcription factor overexpression have become two mains...
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Article
Open AccessLoss-of-function variants in human C12orf40 cause male infertility by blocking meiotic progression
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Article
The effect of carrier characteristics and female age on preimplantation genetic testing results of blastocysts from Robertsonian translocation carriers
To analyze factors affecting segregation and ploidy results from Robertsonian carriers, and determine chromosomes involved impact chromosome stability during meiosis and mitosis.
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Article
Embryo development, pregnancy and live birth outcomes following IVF treatment were not compromised during the COVID-19 pandemic
To evaluate whether outcomes of in vitro fertilization (IVF) are affected during the coronavirus disease-19 (COVID-19) pandemic.
