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Article
Open AccessCheckpoint kinase 2 controls insulin secretion and glucose homeostasis
After the discovery of insulin, a century ago, extensive work has been done to unravel the molecular network regulating insulin secretion. Here we performed a chemical screen and identified AZD7762, a compound...
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Article
Open AccessNKX2-2 based nuclei sorting on frozen human archival pancreas enables the enrichment of islet endocrine populations for single-nucleus RNA sequencing
Current approaches to profile the single-cell transcriptomics of human pancreatic endocrine cells almost exclusively rely on freshly isolated islets. However, human islets are limited in availability. Furtherm...
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Article
Development of PEG-mediated genetic transformation and gene editing system of Bryum argenteum as an abiotic stress tolerance model plant
To establish a sterile culture system and protoplast regeneration system for Bryum argenteum, and to establish and apply CRISPR/Cas9 system in Bryum argenteum.
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Chapter and Conference Paper
Research on the Construction System of Traditional Wooden Dwellings of Miao Nationality in Southeast Guizhou Based on BIM Technology
Traditional wooden dwellings of Miao nationality in southeast Guizhou show unique regional and cultural characteristics, and their main frame form is the Chuan-Dou style wooden frames. In order to analyze the ...
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Article
Open AccessObservation of photonic Peierls transition for manipulating microwave in metallic diaphragm-array periodic structures
Peierls transition that modifies electronic band structure has attracted intensive attention in solid state physics. In the present work, we report that a photonic analog of Peierls transition has been observe...
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Article
Open AccessA kind of planar waveguides for cheating the high-speed digital signals into misidentifying the characteristic impedance
Since a planar periodic transmission line can suppress drastically the electromagnetic coupling, it would be advantageous to use such a kind of transmission lines in solving the problem of miniaturization of c...
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Article
A beta cell subset with enhanced insulin secretion and glucose metabolism is reduced in type 2 diabetes
The pancreatic islets are composed of discrete hormone-producing cells that orchestrate systemic glucose homeostasis. Here we identify subsets of beta cells using a single-cell transcriptomic approach. One sub...
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Chapter and Conference Paper
Integrated Design and Absorbing Performance Analysis for Periodic Wave Absorbing and Bearing Structures
The main development route in wave absorption technology is to develop new absorbing materials to achieve comprehensive requirements such as thin thickness, light weight, broadband coverage and high loss capab...
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Article
Efficient strategies for constrained black-box optimization by intrinsically linear approximation (CBOILA)
In this paper, a novel trust-region-based surrogate-assisted optimization method, called CBOILA (Constrained Black-box Optimization by Intrinsically Linear Approximation), has been proposed to reduce the numbe...
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Article
Single-cell multi-omics analysis of human pancreatic islets reveals novel cellular states in type 1 diabetes
Type 1 diabetes (T1D) is an autoimmune disease in which immune cells destroy insulin-producing beta cells. The aetiology of this complex disease is dependent on the interplay of multiple heterogeneous cell typ...
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Chapter and Conference Paper
LoRa Differential Modulation for LEO Satellite IoT
Due to the wide coverage nature of satellite communication system, Satellite-based Internet of Things (S-IoT) has become a new hot topic in the field of IoT. This paper proposed a differential modulation schem...
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Article
The Role of RNA Epigenetic Modification in Normal and Malignant Hematopoiesis
RNA epigenetic modifications have been identified as novel, dynamic regulators of gene expression, with important impacts on stem cell fate decisions. Here, we examine the functions of RNA modifications, with ...
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Article
Islet transplantation in the subcutaneous space achieves long-term euglycaemia in preclinical models of type 1 diabetes
The intrahepatic milieu is inhospitable to intraportal islet allografts1–3, limiting their applicability for the treatment of type 1 diabetes. Although the subcutaneous space represents an alternate, safe and eas...
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Article
Effects of design parameters on rooftop photovoltaic economics in the urban environment: a case study in Melbourne, Australia
Many researchers found high potential of adopting building photovoltaic (PV) systems in urban areas, especially on building rooftop, to improve the sustainability of urban environment. However, the optimal ene...
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Article
Toll-like receptors TLR2 and TLR4 block the replication of pancreatic β cells in diet-induced obesity
Consumption of a high-energy Western diet triggers mild adaptive β cell proliferation to compensate for peripheral insulin resistance; however, the underlying molecular mechanism remains unclear. In the presen...
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Chapter and Conference Paper
Value Comparison of Distributed Solar Energy Applications in Commercial Buildings Across China
Building sector consumes a significant amount of energy, especially in China. Building photovoltaic (PV) system is considered as a promising solution to improving building energy performance. To increase the ...
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Chapter and Conference Paper
The Impact of Solar PV Design Tilt and Orientation on Project Values
Solar PV as a renewable energy source plays an important role in the reduction of energy consumption and CO2 emissions in buildings. The energy generated by a photovoltaic (PV) panel is affected by its orientatio...
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Article
Open AccessAberrant activation of Notch-1 signaling inhibits podocyte restoration after islet transplantation in a rat model of diabetic nephropathy
Signaling abnormalities play important roles during podocyte injury and have been indicated as crucial events for triggering many glomerular diseases. There is emerging evidence demonstrating significant impro...
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Article
Open AccessIslet transplantation improved penile tissue fibrosis in a rat model of type 1 diabetes
Glycaemic control is one of the most effective strategies for the treatment of diabetes-related erectile dysfunction (DMED). Compared to conventional anti-diabetic drugs and insulin, islet transplantation is m...
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Article
Open AccessDiscovery of a drug candidate for GLIS3-associated diabetes
GLIS3 mutations are associated with type 1, type 2, and neonatal diabetes, reflecting a key function for this gene in pancreatic β-cell biology. Previous attempts to recapitulate disease-relevant phenotypes in GL...
