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Article
Open AccessEnantioselective synthesis of chiral quinohelicenes through sequential organocatalyzed Povarov reaction and oxidative aromatization
Heterohelicenes are of increasing importance in the fields of materials science, molecular recognition, and asymmetric catalysis. However, enantioselective construction of these molecules, especially by organo...
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Article
Open AccessIPSS-M has greater survival predictive accuracy compared with IPSS-R in persons ≥ 60 years with myelodysplastic syndromes
There are considerable new data on mutation topography in persons with myelodysplastic syndromes (MDS). These data have been used to update conventional risk models such as the Revised International Prognostic...
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Article
Open AccessDiagnostic challenge in mixed phenotype acute leukemia with T/megakaryocyte or T/myeloid lineages accompanied by t(3;3)
The diagnosis of mixed phenotype acute leukemia (MPAL) with T/megakaryocyte or T/myeloid lineages accompanied by t(3;3) is always a challenge. Therefore, multiple experimental methods are usually required to a...
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Article
Purine nucleoside analogs plus rituximab are an effective treatment choice for hairy cell leukemia-variant
Both characteristics and optimal treatment strategy for hairy cell leukemia-variant (HCL-v) remain elusive due to its rarity. We retrospectively analyzed the clinical features of HCL-v and the efficacy of firs...
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Article
Open AccessGenetic and virulence characteristics of a Raoultella planticola isolate resistant to carbapenem and tigecycline
Raoultella planticola is an emerging pathogen causing several infections in humans, and its roles in the propagation of antibiotic resistance genes (ARGs) remain uncharacterized. In this study, a carbapenem and t...
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Protocol
Human Hepatocyte Transduction with Adeno-Associated Virus Vector
As the adeno-associated virus (AAV) vectors hold unique advantages over other viral vectors, AAV gene therapy has accumulated rapid progress and development. Liver-targeted gene therapy by AAV vectors has been...
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Article
Open AccessEfficacy of combination of venetoclax with azacitidine or chemotherapy in refractory/relapse acute leukemias of ambiguous lineage, not otherwise specified
Acute leukemias of ambiguous lineage, not otherwise specified (ALAL-NOS) is a rare type of acute leukemia. Management of relapse/refractory (R/R) patients is still challenging.traditional chemotherapy treatmen...
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Article
Engineering adeno-associated virus vectors for gene therapy
Adeno-associated virus (AAV) vector-mediated gene delivery was recently approved for the treatment of inherited blindness and spinal muscular atrophy, and long-term therapeutic effects have been achieved for o...
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Article
Open AccessMultifaceted characterization of the signatures and efficacy of mesenchymal stem/stromal cells in acquired aplastic anemia
Longitudinal studies have verified the pivotal role of mesenchymal stem/stromal cells (MSCs) in the bone marrow microenvironment for hematopoiesis and coordinate contribution to leukemia pathogenesis. However,...
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Article
Superior human hepatocyte transduction with adeno-associated virus vector serotype 7
Although therapeutic outcomes have been achieved in hemophilia patients after delivery of clotting factor genes to the liver using adeno-associated virus (AAV) vectors, it is well known that the preclinical re...
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Article
Open AccessblaNDM-5 carried by a hypervirulent Klebsiella pneumoniae with sequence type 29
A carbapenem-resistant hypermucoviscous Klebsiella pneumoniae isolate was recovered from human sputum.
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Article
Open AccessJNKi- and DAC-programmed mesenchymal stem/stromal cells from hESCs facilitate hematopoiesis and alleviate hind limb ischemia
Mesenchymal stem/stromal cells (MSCs) derived from human embryonic stem cells (hESCs) are attractive for their hematopoietic-supporting or potential therapeutic effects. However, procedures for high-effective ...
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Article
Open AccessBCL-2 and MYC gain/amplification is correlated with central nervous system involvement in diffuse large B cell lymphoma at leukemic phase
Diffuse large B-cell lymphoma (DLBCL) of leukemic phase is a rare clinical manifestation, but is highly prevalent with central nervous system involvement (CNSI). Little is known about this rare clinical observ...
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Article
Monitoring of minimal residual disease in acute myeloid leukemia with t(8;21)(q22;q22)
The fusion gene AML1/ETO is a molecular marker for monitoring minimal residual disease (MRD) in acute myeloid leukemia with the t(8;21)(q22;q22) translocation. To evaluate the dynamic variation and prognostic ...
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Article
Construction of Human Nonimmune Library and Selection of scFvs Against IL-33
Interleukin (IL) 33 plays very important roles in inflammatory and allergic diseases. To select human single-chain Fv fragments (scFvs) against IL-33, a nonimmune phage library system was constructed. The full...
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Article
Reengineering a receptor footprint of adeno-associated virus enables selective and systemic gene transfer to muscle
Gene therapy vectors based on adeno-associated virus tend to accumulate in the liver, limiting their utility for targeting other organs. Using site-directed mutagenesis of the capsid surface, Asokan et al. genera...
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Chapter
Development of AAV vectors for the therapy of autoimmune and inflammatory diseases
Adeno-associated virus (AAV) has been used as a gene delivery vehicle in over 60 human trials as a therapy for neurological, blood, lung, inflammatory, and muscle disorders. In these cases, the AAV vector has ...
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Article
The entrance effect on gases flow characteristics in micro-tube
Entrance region may have important effect on gases flow characteristics in micro-channels. It’s concluded in the available papers that the entrance effect causes significant difference. An experimental system ...
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Article
Adeno-associated virus vectors: potential applications for cancer gene therapy
Augmenting cancer treatment by protein and gene delivery continues to gain momentum based on success in animal models. The primary hurdle of fully exploiting the arsenal of molecular targets and therapeutic tr...
