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Article
Open AccessEpigenetic silencing of LDHB promotes hepatocellular carcinoma by remodeling the tumor microenvironment
Lactate dehydrogenase B (LDHB) reversibly catalyzes the conversion of pyruvate to lactate or lactate to pyruvate and expressed in various malignancies. However, the role of LDHB in modulating immune responses ...
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Article
Open AccessNeoadjuvant tislelizumab plus stereotactic body radiotherapy and adjuvant tislelizumab in early-stage resectable hepatocellular carcinoma: the Notable-HCC phase 1b trial
Notable-HCC (NCT05185531) is a phase 1b trial, aiming to evaluate the safety and preliminary effectiveness of neoadjuvant PD-1 blockade plus stereotactic body radiotherapy (SBRT) in early-stage resectable hepa...
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Article
Open AccessIntegrated transcriptome and metabolome analysis revealed that HaMYB1 modulates anthocyanin accumulation to deepen sunflower flower color
HanMYB1 was found to play positive roles in the modulation of anthocyanins metabolism based on the integrative analysis of different color cultivars and the related molecular genetic analyses.
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Article
Open AccessUSP29 activation mediated by FUBP1 promotes AURKB stability and oncogenic functions in gastric cancer
Gastric cancer is a highly prevalent cancer type and the underlying molecular mechanisms are not fully understood. Ubiquitin-specific peptidase (USP) 29 has been suggested to regulate cell fate in several type...
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Article
SMiT: symmetric mask transformer for disease severity detection
The application of deep learning methods to the intelligent diagnosis of diseases has been the focus of intelligent medical research. When dealing with image classification tasks, if the lesion area is small a...
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Article
Open AccessTAGET: a toolkit for analyzing full-length transcripts from long-read sequencing
Single-molecule Real-time Isoform Sequencing (Iso-seq) of transcriptomes by PacBio can generate very long and accurate reads, thus providing an ideal platform for full-length transcriptome analysis. We present...
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Article
Open AccessReal-world practice of conversion surgery for unresectable hepatocellular carcinoma - a single center data of 26 consecutive patients
To understand the proportion of uHCC (unresectable hepatocellular carcinoma) patients who achieve successful conversion resection in a high-volume setting with state of the art treatment options.
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Article
Open AccessThe emerging role of deubiquitylating enzymes as therapeutic targets in cancer metabolism
Cancer cells must rewire cellular metabolism to satisfy the unbridled proliferation, and metabolic reprogramming provides not only the advantage for cancer cell proliferation but also new targets for cancer tr...
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Article
Open AccessA novel treatment strategy for lapatinib resistance in a subset of HER2-amplified gastric cancer
Gastric cancer (GC) is one of the leading causes of cancer-related deaths worldwide. Human epidermal growth factor receptor 2 (HER2) amplification occurs in approximately 13–23% of all GC cases and patients wi...
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Article
Retraction Note to: External Qi of Yan **n Qigong induces G2/M arrest and apoptosis of androgen-independent prostate cancer cells by inhibiting Akt and NF-
B pathways
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1007/s11010-021-04163-9.
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Article
Open AccessA novel CD4+ CTL subtype characterized by chemotaxis and inflammation is involved in the pathogenesis of Graves’ orbitopathy
Graves’ orbitopathy (GO), the most severe manifestation of Graves’ hyperthyroidism (GH), is an autoimmune-mediated inflammatory disorder, and treatments often exhibit a low efficacy. CD4+ T cells have been rep...
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Article
Open AccessAmplification of transglutaminase 2 enhances tumor-promoting inflammation in gastric cancers
Tumor-promoting inflammation is a hallmark of cancer and is highly associated with tumor progression, angiogenesis, and metastasis. Tumor-associated macrophages (TAMs) are major drivers of tumor-promoting infl...
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Article
Open AccessInsights into the roles of sperm in animal cloning
Somatic cell nuclear transfer (SCNT) has shown a wide application in the generation of transgenic animals, protection of endangered animals, and therapeutic cloning. However, the efficiency of SCNT remains ver...
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Article
Chemical characterization and bioactivities of polysaccharides from Apocynum venetum leaves extracted by different solvents
Apocynum venetum has a long history as a Chinese traditional tea. As one of the major components, polysaccharides from Apocynum venetum leaves were extracted with acid (HCl), distilled water and alkaline (NaOH) t...
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Article
Characterization of recombinant glutathione reductase from Antarctic yeast Rhodotorula mucilaginosa
Glutathione reductase (GR) catalyzes the reduction of glutathione disulfide, which helps to maintain a cellular reducing environment during stress in organisms. However, GR of polar yeast has not been well-cha...
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Article
Open AccessMulti-platform discovery of haplotype-resolved structural variation in human genomes
The incomplete identification of structural variants (SVs) from whole-genome sequencing data limits studies of human genetic diversity and disease association. Here, we apply a suite of long-read, short-read, ...
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Article
Open AccessNatural variations of FT family genes in soybean varieties covering a wide range of maturity groups
Flowering time and maturity are among the most important adaptive traits in soybean (Glycine max (L.) Merill). Flowering Locus T (FT) family genes function as key flowering integrators, with flowering-promoting m...
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Chapter and Conference Paper
Research on CFD Steady-State Simulation Analysis and Optimization for Defrosting of Passenger Vehicles
By comparing defrosting CFD steady-state, transient simulation and vehicle climate test results, the method of predicting transient defrosting time by steady-state analysis is proposed, and the structure of de...
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Article
Open AccessHigh-resolution deconstruction of evolution induced by chemotherapy treatments in breast cancer xenografts
The processes by which tumors evolve are essential to the efficacy of treatment, but quantitative understanding of intratumoral dynamics has been limited. Although intratumoral heterogeneity is common, quantif...
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Article
Open AccessMiR-98 modulates macrophage polarization and suppresses the effects of tumor-associated macrophages on promoting invasion and epithelial–mesenchymal transition of hepatocellular carcinoma
Tumor-associated macrophages (TAMs) are generally recognized as a promoter of tumor progression. miR-98 has been shown to suppress the proliferation, migration, invasion and epithelial–mesenchymal transition (...
