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Article
Open AccessREMAS: a new regression model to identify alternative splicing events from exon array data
Alternative splicing (AS) is an important regulatory mechanism for gene expression and protein diversity in eukaryotes. Previous studies have demonstrated that it can be causative for, or specific to splicing-...
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Article
Open AccessTranscription and splicing regulation in human umbilical vein endothelial cells under hypoxic stress conditions by exon array
The balance between endothelial cell survival and apoptosis during stress is an important cellular process for vessel integrity and vascular homeostasis, and it is also pivotal in angiogenesis during the devel...
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Article
Open AccessMPprimer: a program for reliable multiplex PCR primer design
Multiplex PCR, defined as the simultaneous amplification of multiple regions of a DNA template or multiple DNA templates using more than one primer set (comprising a forward primer and a reverse primer) in one...
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Article
Open AccessA proteomic view of Caenorhabditis elegans caused by short-term hypoxic stress
The nematode Caenorhabditis elegans is both sensitive and tolerant to hypoxic stress, particularly when the evolutionarily conserved hypoxia response pathway HIF-1/EGL-9/VHL is involved. Hypoxia-induced changes i...
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Article
Open AccessReliability analysis of the Ahringer Caenorhabditis elegans RNAi feeding library: a guide for genome-wide screens
The Ahringer C. elegans RNAi feeding library prepared by cloning genomic DNA fragments has been widely used in genome-wide analysis of gene function. However, the library has not been thoroughly validated by dire...
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Article
Open AccessStudy on Enzymatic Degradation of Cornstalk in Ionic Liquid
The influence of reaction conditions on the enzymatic degradation of cornstalk in the system of 1-ethyl-3-methylimidazolium acetate ([EMIM]OAc) was investigated. The optimum condition was as follows: 5 g 4 wt%...
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Article
Open AccessIntrathecal decompression versus epidural decompression in the treatment of severe spinal cord injury in rat model: a randomized, controlled preclinical research
In the setting of severe spinal cord injury (SCI), there is no markedly efficacious clinical therapeutic regimen to improve neurological function. After epidural decompression, as is shown in animal models, th...
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Article
Open AccessMolecular Subty** of Serous Ovarian Cancer Based on Multi-omics Data
Classification of ovarian cancer by morphologic features has a limited effect on serous ovarian cancer (SOC) treatment and prognosis. Here, we proposed a new system for SOC subty** based on the molecular cat...
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Article
Open AccessAntibacterial activity identification of pCM19 and pCM12 derived from hGlyrichin
hGlyrichin is a novel human antimicrobial peptide rich in glycine. The previous study of known human antimicrobial peptides indicated that in an eligible range, the greater corresponding antibacterial activity...
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Article
Open AccessHigh yields and soluble expression of superoxide dismutases in Escherichia coli due to the HIV-1 Tat peptide via increases in mRNA transcription
This study aimed to validate the high yield and soluble expression of proteins carrying the transactivator of transcription (Tat) peptide tag, and further explored the potential mechanism by which the Tat tag ...
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Article
Open AccessUncovering the cognitive processes underlying mental rotation: an eye-movement study
Mental rotation is an important paradigm for spatial ability. Mental-rotation tasks are assumed to involve five or three sequential cognitive-processing states, though this has not been demonstrated experiment...
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Article
Open AccessAssociation between dipsacus saponin VI level and diversity of endophytic fungi in roots of Dipsacus asperoides
Dipsacus asperoides contains multiple pharmacologically active compounds. The principal are saponins. The plant can be cultivated, but it contains lower levels of bioactive compounds than the plant in the wild. I...
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Article
Open AccessLymph node ratio is a prospective prognostic indicator for locally advanced gastric cancer patients after neoadjuvant chemotherapy
The accuracy of lymph node ratio (LNR) as a prognostic index remains to be proven for gastric cancer patients after neoadjuvant chemotherapy (NACT). This study sought to investigate the prognostic value of LNR...
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Open AccessLaparoscopic versus open gastrectomy for locally advanced gastric cancer after neoadjuvant chemotherapy: a comprehensive contrastive analysis with propensity score matching
Laparoscopic gastrectomy (LG) is increasingly applied in locally advanced gastric cancer (LAGC) after neoadjuvant chemotherapy (NC). However, there is no study to comprehensively evaluate the clinicopathologic...
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Article
Open AccessHigh-frequency low-dielectric-loss in linear-backbone-structured polyimides with ester groups and ether bonds
Polyimides have emerged as promising dielectric materials for communication equipment, owing to their excellent thermal stability and processability. Nonetheless, a pressing need remains to reduce the high-fre...
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Open AccessLong-term relapse-free survival enabled by integrating targeted antibacteria in antitumor treatment
The role of tumor-resident intracellular microbiota (TRIM) in carcinogenesis has sparked enormous interest. Nevertheless, the impact of TRIM-targeted antibacteria on tumor inhibition and immune regulation in t...
