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Article
Improved optimal foraging algorithm for global optimization
The optimal foraging algorithm (OFA) is a swarm-based algorithm motivated by animal behavioral ecology theory. When solving complex optimization problems characterized by multiple peaks, OFA is easy to get tra...
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Article
Open AccessPan-cancer analysis combined with experiments predicts NNMT as a therapeutic target for human cancers
The identification of effective therapeutic targets plays a pivotal role in advancing cancer treatment outcomes. We employed a comprehensive pan-cancer analysis, complemented by experimental validation, to exp...
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Article
A comparative study of locking plate combined with minimally invasive plate osteosynthesis and intramedullary nail fixation in the treatment of Neer classification of two-part and three-part fractures of the proximal humerus
To compare the clinical efficacy of the minimally invasive locking plate technique (Philos plate) and interlocking intramedullary nailing technique (TRIGEN intramedullary nail) in the treatment of Neer two-par...
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Article
Open AccessPlasma proteome profiling reveals dynamic of cholesterol marker after dual blocker therapy
Dual blocker therapy (DBT) has the enhanced antitumor benefits than the monotherapy. Yet, few effective biomarkers are developed to monitor the therapy response. Herein, we investigate the DBT longitudinal pla...
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Article
Open AccessDoes obstructive sleep apnea–induced intermittent hypoxia increase the incidence of solitary pulmonary nodules, thyroid nodules, and other disorders? A retrospective study based on 750 cardiovascular disease patients
Obstructive sleep apnea (OSA) has been shown to be an important risk factor for cardiovascular disease (CVD), and intermittent hypoxia is an important pathogenetic factor for it. In the clinic, it was found th...
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Article
Open AccessIdentification and analysis of MSC-Exo-derived LncRNAs related to the regulation of EMT in hypospadias
This study aims to screen the differentially expressed long non-coding RNAs (DELncRNAs) related to the regulation of epithelial-mesenchymal transition (EMT) in hypospadias in mesenchymal stem cell-derived exos...
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Article
Set7/9 aggravates ischemic brain injury via enhancing glutamine metabolism in a blocking Sirt5 manner
The aberrant expression of methyltransferase Set7/9 plays a role in various diseases. However, the contribution of Set7/9 in ischemic stroke remains unclear. Here, we show ischemic injury results in a rapid el...
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Article
Open AccessNephroblastoma-specific dysregulated gene SNHG15 with prognostic significance: scRNA-Seq with bulk RNA-Seq data and experimental validation
Wilms tumor (WT) is the most common malignancy of the genitourinary system in children. Currently, the Integration of single-cell RNA sequencing (scRNA-Seq) and Bulk RNA sequencing (RNA-Seq) analysis of hetero...
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Article
Open AccessCase study on long-term deformation monitoring and numerical simulation of layered rock slopes on both sides of Wudongde dam reservoir area
Layered rock slope exists widely. Because of its special slope structure, it is prone to bending deformation and toppling failure, which is a serious threat to engineering construction and safety operation. At...
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Article
Open AccessProteomic characterization of esophageal squamous cell carcinoma response to immunotherapy reveals potential therapeutic strategy and predictive biomarkers
Immunotherapy is the first-line therapy for esophageal squamous cell carcinoma (ESCC), yet many patients do not respond due to drug resistance and the lack of reliable predictive markers. We collected 73 ESCC ...
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Article
An Interpretable Screening Approach Derived Through XGBoost Regression for the Discovery of Hypolipidemic Contributors in Chinese Hawthorn Leaf and its Counterfeit Malus Doumeri Leaf
The active ingredient group is a prominent feature reflecting the inherent characteristics of plant-based functional foods. Chinese hawthorn leaf (CHL), a tea substitute possessing intrinsic nutritional proper...
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Article
Open AccessProteomic characterization identifies clinically relevant subgroups of soft tissue sarcoma
Soft tissue sarcoma is a broad family of mesenchymal malignancies exhibiting remarkable histological diversity. We portray the proteomic landscape of 272 soft tissue sarcomas representing 12 major subtypes. Hi...
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Article
Open AccessLongitudinal plasma proteome profiling reveals the diversity of biomarkers for diagnosis and cetuximab therapy response of colorectal cancer
Cetuximab therapy is the major treatment for colorectal cancer (CRC), but drug resistance limits its effectiveness. Here, we perform longitudinal and deep proteomic profiling of 641 plasma samples originated f...
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Article
Open AccessRibosome profiling: a powerful tool in oncological research
Neoplastic cells need to adapt their gene expression pattern to survive in an ever-changing or unfavorable tumor microenvironment. Protein synthesis (or mRNA translation), an essential part of gene expression,...
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Develo** Tree Improvement Strategies for Challenging Environmental Stresses Under Global Climate Change: A Review from Traditional Tree Breeding to Genomics of Adaptive Traits for the Quaking Aspen
Quaking or trembling aspen in North America and Euro-Asia (Populus tremuloides and P. tremula, respectively) are both widely distributed species with a long history of scientific research and tree improvement wor...
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Article
Dbias: detecting biases and ensuring fairness in news articles
Because of the increasing use of data-centric systems and algorithms in machine learning, the topic of fairness is receiving a lot of attention in the academic and broader literature. This paper introduces Dbi...
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Article
Open AccessAnterior cervical X-shape-corpectomy and fusion vs. anterior cervical corpectomy and fusion for two-level cervical spondylosis
Anterior cervical X-shape-corpectomy and fusion (ACXF) is a novel cervical surgery, designed as partial alternative to the classic technique, anterior cervical corpectomy and fusion (ACCF). The aim of this study ...
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Article
Open AccessMicroglia are not protective against cryptococcal meningitis
Microglia provide protection against a range of brain infections including bacteria, viruses and parasites, but how these glial cells respond to fungal brain infections is poorly understood. We investigated th...
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Article
6-Methyl flavone inhibits Nogo-B expression and improves high fructose diet-induced liver injury in mice
Excessive fructose consumption increases hepatic de novo lipogenesis, resulting in cellular stress, inflammation and liver injury. Nogo-B is a resident protein of the endoplasmic reticulum that regulates its s...
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Open AccessResearch on fire resistance and economy of basalt fiber insulation mortar
The construction sector has become the most critical source of carbon emissions, but the existing thermal insulation materials such as thermal insulation mortar have obvious limitations, so it is urgent to dev...
