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  1. Article

    Open Access

    Safety of sildenafil in premature infants with severe bronchopulmonary dysplasia (SILDI-SAFE): a multicenter, randomized, placebo-controlled, sequential dose-escalating, double-masked, safety study

    Pulmonary hypertension is a deadly complication of bronchopulmonary dysplasia, the most common pulmonary morbidity of prematurity. Despite these catastrophic consequences, no evidence-based therapies are avail...

    Simone Schneider, Mary Bailey, Tracy Spears, Charles R. Esther Jr… in BMC Pediatrics (2020)

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  2. No Access

    Chapter

    Regulation of Airway Nucleotides in Chronic Lung Diseases

    The physiological relevance of the purinergic signaling network for airway defenses is emerging through cumulating reports of abnormal ATP and adenosine (ADO) levels in the airway secretions of patients with a...

    Charles R. Esther Jr., Neil E. Alexis… in Purinergic Regulation of Respiratory Disea… (2011)

  3. No Access

    Chapter

    Nucleotide Release by Airway Epithelia

    The purinergic events regulating the airways’ innate defenses are initiated by the release of purines from the epithelium, which occurs constitutively and is enhanced by chemical or mechanical stimulation. Whi...

    Eduardo R. Lazarowski, Juliana I. Sesma… in Purinergic Regulation of Respiratory Disea… (2011)