15 Result(s)
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Eduardo R. Lazarowski
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Article
Open AccessAuthor Correction: Age-related mitochondrial alterations in brain and skeletal muscle of the YAC128 model of Huntington disease
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Article
Open AccessAge-related mitochondrial alterations in brain and skeletal muscle of the YAC128 model of Huntington disease
Mitochondrial dysfunction and bioenergetics failure are common pathological hallmarks in Huntington’s disease (HD) and aging. In the present study, we used the YAC128 murine model of HD to examine the effects ...
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Article
UDP-glucose promotes neutrophil recruitment in the lung
In addition to their role in glycosylation reactions, UDP-sugars are released from cells and activate widely distributed cell surface P2Y14 receptors (P2Y14R). However, the physiological/pathophysiological conseq...
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Article
PPAR-δ is repressed in Huntington's disease, is required for normal neuronal function and can be targeted therapeutically
PPAR-δ activity is impaired by mutant huntingtin, and a PPAR-δ agonist attenuates disease in a mouse model of Huntington's disease.
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Article
Vesicular and conductive mechanisms of nucleotide release
Extracellular nucleotides and nucleosides promote a vast range of physiological responses, via activation of cell surface purinergic receptors. Virtually all tissues and cell types exhibit regulated release of...
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Article
Open AccessToll-Like Receptor 4 Engagement Inhibits Adenosine 5′-Monophosphate-Activated Protein Kinase Activation through a High Mobility Group Box 1 Protein-Dependent Mechanism
Despite the potent antiinflammatory effects of pharmacologically induced adenosine 5′-monophosphate kinase (AMPK) activation on Toll-like receptor 4 (TLR4)-induced cellular activation, there is little evidence...
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Chapter
Nucleotide Release by Airway Epithelia
The purinergic events regulating the airways’ innate defenses are initiated by the release of purines from the epithelium, which occurs constitutively and is enhanced by chemical or mechanical stimulation. Whi...
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Chapter
Computational Model for the Regulation of Extracellular ATP and Adenosine in Airway Epithelia
Extracellular nucleotides are key components of the signaling network regulating airway clearance. They are released by the epithelium into the airway surface liquid (ASL) to stimulate cilia beating activity, ...
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Article
Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis
Apoptotic cells were shown recently to discharge the nucleotides ATP and UTP to act as 'find-me' signals for phagocytes that engulf dying cells before they release potentially harmful cellular contents. This p...
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Article
Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance
Apoptosis occurs in essentially all tissues as part of normal development and homeostasis. Yet even in tissues with high cellular turnover, apoptotic cells are rarely seen; this has been attributed to the abil...
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Assessment of Extracellular ATP Concentrations
Most cells release ATP to the extracellular milieu. Extracellular ATP plays important signaling roles by activating a score of broadly distributed cell surface purinergic receptors (purinoceptors). Biological ...
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Article
Basal Nucleotide Levels, Release, and Metabolism in Normal and Cystic Fibrosis Airways
Cystic fibrosis (CF) is a syndrome caused by mutations in the cystic fibrosis transmembrane regulator (CFTR) gene. Despite advances in our understanding of the molecular pathogenesis of CF, the link between CF...
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Article
G-protein-coupled receptors as targets for gene transfer vectors using natural small-molecule ligands
Gene therapy for cystic fibrosis (CF) has focused on correcting electrolyte transport in airway epithelia. However, success has been limited by the failure of vectors to attach and enter into airway epithelia,...
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Chapter
Pharmacological Selectivities of Molecularly Defined Subtypes of P2Y Receptors
Burnstock and Kennedy (1985) proposed the first formal subtype expansion past the P2-purinoceptor concept originated by Burnstock (1978). The idea that a subset of P2X and P2Y receptors could account for the p...
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Membrane-restricted regulation of Ca2+ release and influx in polarized epithelia
EPITHELIAL cells exist in a complex setting in which responses to mucosal or serosal environments are mediated by receptors expressed on specialized cellular domains, such as apical versus basolateral cell me...
