60 Result(s)

Article

Physical and Enzymatic Studies on Poly d(I–C).Poly d(I–C), an Unusual Double-helical DNA

X-ray diffraction and circular dichroism studies indicate that poly d(I–C).poly d(I–C) exists in a new polynucleotide configuration—an eight-fold helix, possibly left-handed.

Y. MITSUI, R. LANGRIDGE, BARBARA E. SHORTLE, CHARLES R. CANTOR, ROBERT C. GRANT… in Nature (1970)

Chapter

Interaction of N-2-Acetylaminofluorene with RNA

Several carcinogens bind in vivo to nucleic acids, proteins, and carbohydrates (Miller and Miller, 1967; Farber, 1968). The binding of these agents to nucleic acids is of particular interest, owing to the central...

Dezider Grunberger, I. Bernard Weinstein… in Proceedings of the Research Symposium on C… (1971)

Chapter

Studies on tRNA Structure Using Covalently and Noncovalently Bound Fluorescent Dyes

For the past few years, we have been interested in develo** techniques which can provide information about the tertiary structure of nucleic acids in solution. The use of fluorescent labels would appear at t...

Charles R. Cantor, Kenneth Beardsley… in Proceedings of the Research Symposium on C… (1971)

Article

Affinity labelling the acceptor site of the peptidyl transferase centre of the Escherichia coli ribosome

WE have identified two 50S proteins, L2 and L26-L27, in the peptidyl (P) site of the peptidyl transferase centre of E. coli ribosomes¹ BrAc-³H-Phe-tRNA^phe, a peptidyl-tRNA affinity analogue, was shown to bind spe...

DAN EILAT, MARIA PELLEGRINI, HELEN OEN, NATHAN DE GROOT, YEHUDA LAPIDOT… in Nature (1974)

Article

Surface topography of the Bacillus stearothermophilus ribosome

The surface topography of the intact 70S ribosome and free 30S and 50S subunits from Bacillus stearothermophilus strain 2184 was investigated by lactoperoxidase-catalyzed iodination. Two-dimensional polyacrylamid...

Hugh M. Miller, S. Marvin Friedman, David J. Litman… in Molecular and General Genetics MGG (1976)

Article

Huntington's disease: Charting the path to the gene

Charles R. Cantor in Nature (1984)

Article

Pulsed-field gel electrophoresis of large DNA molecules

A new development in gel electrophoresis allows investigators to fractionate and analyse DNA species from 10,000 to more than a million base pairs.

Cassandra L. Smith, Charles R. Cantor in Nature (1986)

Article

Delivery of photoreactive psoralen derivatives to specific biological targets

Psoralens are bifunctional molecules which photoreact with the pyrimidine bases of nucleic acids to form monoadducts and diadducts, or interstrand cross-links. We have prepared psoralen derivatives with additi...

Wilma A. Saffran, Cho-Fat Hui, Richard L. Edelson… in Journal of Protein Chemistry (1986)

Chapter and Conference Paper

Map** the Genome

At the outset it is important to restate why we want to map the human genome and what such maps will tell us. There are many different types of genomic maps. A map is basically a sketch of the genome. Like a g...

Charles R. Cantor, Cassandra L. Smith in Biotechnology and the Human Genome (1988)

Article

Techniques for map** the structure of entire genomes

Charles R. Cantor, Cassandra L. Smith in Fresenius' Zeitschrift für analytische Chemie (1988)

Chapter

Torsional Stress, Unusual DNA Structures, and Eukaryotic Gene Expression

Torsional stress in DNA plays a significant role in regulating gene expression in prokaryotes. It has been known for more than a decade that different promoters show a differential response to the level of in viv...

Charles R. Cantor, Subhasis Bondopadhyay, Shamir K. Bramachari… in Unusual DNA Structures (1988)

Chapter

Organization and Evolution of Genomes as seen from a Megabase Perspective

It seems appropriate that the evolutionary pattern of gene expression is the focus of this special workshop to commemorate many years of molecular biology advanced study institutes on Spetses. These institutes...

Charles R. Cantor, Larysa Pevny… in Evolutionary Tinkering in Gene Expression (1989)