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Article
Open AccessAge-related injury responses of human oligodendrocytes to metabolic insults: link to BCL-2 and autophagy pathways
Myelin destruction and oligodendrocyte (OL) death consequent to metabolic stress is a feature of CNS disorders across the age spectrum. Using cells derived from surgically resected tissue, we demonstrate that ...
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Article
Open AccessAuthor Correction: Single-cell RNA-seq reveals that glioblastoma recapitulates a normal neurodevelopmental hierarchy
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessSingle-cell RNA-seq reveals that glioblastoma recapitulates a normal neurodevelopmental hierarchy
Cancer stem cells are critical for cancer initiation, development, and treatment resistance. Our understanding of these processes, and how they relate to glioblastoma heterogeneity, is limited. To overcome the...
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Article
MAFG-driven astrocytes promote CNS inflammation
Multiple sclerosis is a chronic inflammatory disease of the CNS1. Astrocytes contribute to the pathogenesis of multiple sclerosis2, but little is known about the heterogeneity of astrocytes and its regulation. He...