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Article
Open AccessTransgenic livestock for agriculture and biomedical applications
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Article
Transgenic sheep generated by lentiviral vectors: safety and integration analysis of surrogates and their offspring
The safety of HIV-1 based vectors was evaluated during the production of transgenic sheep. Vectors were introduced into the perivitelline space of in vivo derived one-cell sheep embryos by microinjection then ...
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Article
Expression of human FUS/TLS in yeast leads to protein aggregation and cytotoxicity, recapitulating key features of FUS proteinopathy
Mutations in the fused in sarcoma/translocated in liposarcoma (FUS/TLS) gene have been associated with amyotrophic lateral sclerosis (ALS). FUS-positive neuropathology is reported in a range of neurodegenerati...
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Article
The effect of glycerol on cochlear function and ionic concentration
The use of glycerol continues to be a popular clinical test for diagnosing reversible hearing loss in patients with Meniere's disease, although its mechanism of action remains obscure. The purpose of this inve...
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Article
A Hypodermic Probe using Fibre Optics
IT has long been the desire of physicians, physiologists, and biophysicists alike to be able to observe, microscopically, living human tissue in its original environment. Numerous ingenious approaches to the p...
