Summary
The use of glycerol continues to be a popular clinical test for diagnosing reversible hearing loss in patients with Meniere's disease, although its mechanism of action remains obscure. The purpose of this investigation was to study experimentally the alterations in the ionic composition and function of the cochlea which occur following glycerol administration. Immediate decreases in inner ear pressure and increases in AP threshold were seen. Delayed decreases in the endocochlear potential with increases in inner ear electrolytes occurred. However, we were unable to find any substantial changes in inner ear oxygen concentrations. Our findings support the concept that the principal action of glycerol is in osmotic reduction of inner ear pressure.
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References
Allen GW, Habibi M (1962) The effect of increasing CSF pressure upon the cochlear microphonics. Laryngoscope 72:423–434
Angelborg C (1981) Role of hyperosmolar solutions in induced threshold shift. In: Vosteen KH, Schuknecht H, Pfaltz CR, Wersäll J, Kimura RS, Morgenstern C, Juhn SK (eds) Meniere's disease: pathogenesis, diagnosis and treatment. Thieme-Stratton Inc, New York, pp 86–98
Angelborg C, Angerup B (1975) Glycerol effects on perilymphatic and cerebrospinal fluid pressure. Acta Otolaryngol (Stockh) 79:81–87
Booth JB (1980) Meniere's disease: the selection and assessment of patients for surgery using electrocochleography. Ann R Coll Surg 62:415–425
Carlborg BI, Farmer JC (1983) Effects of hyperosmolar solutions on the labyrinthine fluid pressure. I. Effects of glycerol and urea tests. Ann Oto-Rhino-Laryngol [Suppl] 92:104
Carlborg B, Farmer C (1983) Relationships of labyrinthine fluid pressure and blood flow. Laryngoscope 93:998–1003
Coates A, Alford BR (1981) Meniere's disease and the summating potential: effects of glycerol administration. Arch Otolaryngol 107:469–473
Duvall AJ, Santi PA, Hukee MJ (1980) Cochlear fluid balance: a clinical overview. Ann Otol Rhinol Laryngol 89:335–341
Juhn SK, Prado S, Pearce J (1976) Osmolality changes in perilymph after systemic administration of glycerin. Arch Otolaryngol 102:683–685
Kimura RS (1982) Animal models of endolymphatic hydrops. Am J Otolaryngol 3:447–451
Klockhoff I (1981) Glycerol test—some remarks after 15 years experience. In: Vosteen KH, Schuknecht H, Pfaltz CR, Wersäll J, Kimura RS, Morgenstern C, Juhn SK (eds) Meniere's disease: pathogenesis, diagnosis and treatment. Thieme-Stratton Inc, New York, pp 148–151
Klockhoff I, Lindblom U, (1966) Endolymphatic hydrops as revealed by the glycerol test. Acta Otolaryngol (Stockh) 61:459–462
Larsen HC, Angelborg C, Hultcrantz E (1982) Cochlear blood flow related to hyperosmolar solutions. Arch Otorhinolaryngol 234:145–150
Lawrence M (1980) Inner ear physiology. In: Paparella MM, Shumrick DA (eds) Otolaryngology, vol 1. WB Saunders Co, Philadelphia, pp 216–240
Mellander S (1970) Systemic circulation: local control. Ann Rev Physiol 32:313
Moffat DA, Gibson WPR, Romsden RT, Morrison AW, Booth J (1978) Transtympanic electrocochleography during glycerol dehydration. Acta Otolaryngol (Stockh) 85:158–166
Morizono T, Matsumoto I, Sellick PM, Johnstone BM (1974) Measurement of potassium ion concentration in the inner ear fluid with liquid ion-exchanger microelectrodes. Otol Fukuoka 20:128–132
Morrison AW, Moffat DA, O'Connor A (1980) Clinical usefulness of electrocochleography in Meniere's disease: an analysis of dehydrating agents. Otolaryngol Clin North Am 13:703–721
Prazma J (1981) Effect of glycerol on cochlear microcirculation. Acta Otolaryngol (Stockh) 92:459–461
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Cohen, J., Morizono, T. & Long, C. The effect of glycerol on cochlear function and ionic concentration. Arch Otorhinolaryngol 241, 285–293 (1985). https://doi.org/10.1007/BF00453702
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DOI: https://doi.org/10.1007/BF00453702