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Article
Open AccessThe clinical utility of cystatin C based eGFR in assessing renal function among HIV/AIDs patients on ART at Mildmay Uganda
In clinical practice, Measurement of estimated glomerular filtration rates (eGFR) is the gold standard assessing renal function the glomerular filtration rate often estimated from plasma creatinine. Several st...
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Article
Open AccessPlasmodium falciparum genetic diversity and multiplicity of infection based on msp-1, msp-2, glurp and microsatellite genetic markers in sub-Saharan Africa: a systematic review and meta-analysis
In sub-Saharan Africa (SSA), Plasmodium falciparum causes most of the malaria cases. Despite its crucial roles in disease severity and drug resistance, comprehensive data on Plasmodium falciparum genetic diversit...
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Article
Open AccessAdherence to malaria management guidelines by health care workers in the Busoga sub-region, eastern Uganda
Appropriate malaria management is a key malaria control strategy. The objective of this study was to determine health care worker adherence levels to malaria case management guidelines in the Busoga sub-region...
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Article
Open AccessAssessment of the accuracy of malaria microscopy in private health facilities in Entebbe Municipality, Uganda: a cross-sectional study
Although microscopy remains the gold standard for malaria diagnosis, little is known about its accuracy in the private health facilities in Uganda. This study evaluated the accuracy of malaria microscopy, and ...
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Article
Open AccessGenetic diversity and genetic relatedness in Plasmodium falciparum parasite population in individuals with uncomplicated malaria based on microsatellite ty** in Eastern and Western regions of Uganda, 2019–2020
Genetic diversity and parasite relatedness are essential parameters for assessing impact of interventions and understanding transmission dynamics of malaria parasites, however data on its status in Plasmodium fal...
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Article
Open AccessQuality of care for adult in-patients with malaria in a tertiary hospital in Uganda
Prompt detection and appropriate treatment of malaria prevents severe disease and death. The quality of care for adult malaria in-patients is not well documented in sub-Saharan Africa, particularly in Uganda. ...
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Article
Open AccessThe clinical spectrum of severe childhood malaria in Eastern Uganda
Few recent descriptions of severe childhood malaria have been published from high-transmission regions. In the current study, the clinical epidemiology of severe malaria in Mbale, Eastern Uganda, is described,...
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Article
Open AccessMolecular surveillance reveals the presence of pfhrp2 and pfhrp3 gene deletions in Plasmodium falciparum parasite populations in Uganda, 2017–2019
Histidine-rich protein-2 (HRP2)-based rapid diagnostic tests (RDTs) are the only RDTs recommended for malaria diagnosis in Uganda. However, the emergence of Plasmodium falciparum histidine rich protein 2 and 3 (p...
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Article
Open AccessSystematic review of the status of pfhrp2 and pfhrp3 gene deletion, approaches and methods used for its estimation and reporting in Plasmodium falciparum populations in Africa: review of published studies 2010–2019
Malaria rapid diagnostic tests based on histidine-rich protein-2 have played a vital role in improving malaria case management and surveillance particularly in Africa, where Plasmodium falciparum is predominant. ...
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Article
Open AccessLoss to follow-up and associated factors among adult people living with HIV at public health facilities in Wakiso district, Uganda: a retrospective cohort study
Loss to follow-up (LTFU) from care among people living with HIV (PLHIV) is thought to be more common in the public setting compared to the private health care. It is anticipated that the problem may become wor...
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Article
Open AccessCaregiver responses and association with delayed care-seeking in children with uncomplicated and severe malaria
Gaps remain in understanding the role of caregiver responses on time to seek appropriate care. The objective of this study was to describe caregiver responses to illness and the impact of these responses on ti...
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Article
Open AccessBurden and factors associated with clinical neonatal sepsis in urban Uganda: a community cohort study
Neonatal sepsis is one of the most important causes of mortality in develo** countries and yet the most preventable. In develo** countries clinical algorithms are used to diagnose clinical neonatal sepsis ...
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Article
Open AccessHigh rate of inappropriate blood transfusions in the management of children with severe anemia in Ugandan hospitals
Severe anaemia (SA) is a common reason for hospitalisation of children in sub-Saharan Africa but the extent to which blood transfusion is used appropriately in the management of severe anemia has hitherto rema...
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Article
Open AccessMeasurement error of mean sac diameter and crown-rump length among pregnant women at Mulago hospital, Uganda
Ultrasonography is essential in the prenatal diagnosis and care for the pregnant mothers. However, the measurements obtained often contain a small percentage of unavoidable error that may have serious clinical...
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Article
Open AccessRisk factors, person, place and time characteristics associated with Hepatitis E Virus outbreak in Napak District, Uganda
Hepatitis E is self-limiting, but can cause death in most at risk groups like pregnant women and those with preexisting acute liver disease. In develo** countries it presents as epidemic, in 2014 Hepatitis E...
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Article
Open AccessWasting, underweight and stunting among children with congenital heart disease presenting at Mulago hospital, Uganda
Children with congenital heart disease are at increased risk of malnutrition. The aim of this study was to describe the prevalence of wasting, underweight and stunting among children with congenital heart dise...
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Article
Open AccessHerbal medicine use and linked suspected adverse drug reactions in a prospective cohort of Ugandan inpatients
Clinical history-taking can be employed as a standardized approach to elucidate the use of herbal medicines and their linked suspected adverse drug reactions (ADRs) among hospitalized patients. We sought to id...
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Article
Open AccessPrevalence of arrhythmias among children below 15 years of age with congenital heart diseases attending Mulago National Referral Hospital, Uganda
In Uganda, few children with congenital heart diseases (CHD) benefit from early corrective cardiac surgery. These children are at high risk of develo** heart failure and electrolyte imbalances; factors which...
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Article
Open AccessThe epidemiology of rotavirus disease in under-five-year-old children hospitalized with acute diarrhea in central Uganda, 2012-2013
A cross-sectional study was undertaken during 2012-2013 to determine the prevalence, strains and factors associated with rotavirus infection among under-5-year-old children hospitalized with acute diarrhea in ...
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Article
Open AccessMedication Error Disclosure and Attitudes to Reporting by Healthcare Professionals in a Sub-Saharan African Setting: A Survey in Uganda
Medication errors (MEs) are largely under-reported, which undermines quality improvement and medication risk management in healthcare.
