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Article
Open AccessREDD1 promotes obesity-induced metabolic dysfunction via atypical NF-κB activation
Regulated in development and DNA damage response 1 (REDD1) expression is upregulated in response to metabolic imbalance and obesity. However, its role in obesity-associated complications is unclear. Here, we d...
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Article
Novel chemical scaffolds of the tumor marker AKR1B10 inhibitors discovered by 3D QSAR pharmacophore modeling
Recent evidence suggests that aldo-keto reductase family 1 B10 (AKR1B10) may be a potential diagnostic or prognostic marker of human tumors, and that AKR1B10 inhibitors offer a promising choice for treatment o...
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Article
Open AccessStructural importance of the C-terminal region in pig aldo-keto reductase family 1 member C1 and their effects on enzymatic activity
Pig aldo-keto reductase family 1 member C1 (AKR1C1) belongs to AKR superfamily which catalyzes the NAD(P)H-dependent reduction of various substrates including steroid hormones. Previously we have reported two ...
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Article
New insights in the activation of human cholesterol esterase to design potent anti-cholesterol drugs
Primary hypercholesterolemia is the root cause for major health issues like coronary heart disease and atherosclerosis. Regulating plasma cholesterol level, which is the product of biosynthesis as well as diet...
