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New insights in the activation of human cholesterol esterase to design potent anti-cholesterol drugs
Primary hypercholesterolemia is the root cause for major health issues like coronary heart disease and atherosclerosis. Regulating plasma cholesterol level, which is the product of biosynthesis as well as diet...
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Article
Open AccessDevelopment, evaluation and application of 3D QSAR Pharmacophore model in the discovery of potential human renin inhibitors
Renin has become an attractive target in controlling hypertension because of the high specificity towards its only substrate, angiotensinogen. The conversion of angiotensinogen to angiotensin I is the first an...
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Article
Open AccessPotent bace-1 inhibitor design using pharmacophore modeling, in silico screening and molecular docking studies
Beta-site amyloid precursor protein cleaving enzyme (BACE-1) is a single-membrane protein belongs to the aspartyl protease class of catabolic enzymes. This enzyme involved in the processing of the amyloid prec...
