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Article
Open AccessAspirin inhibits rotavirus replication and alters rat gut microbial composition
Aspirin is widely used to treat various clinical symptoms. Evidence suggests that aspirin has antiviral properties, but little is known about its specific effect against rotavirus.
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Article
Open AccessAnalysis of the intestinal microbial community altered during rotavirus infection in suckling mice
Rotavirus (RV) is a principal cause of diarrhea. However, there is a limited understanding regarding alteration of the gut microbial community structure and abundance during RV infection. This study was to cha...
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Article
Reprogramming the enzymatic assembly line for site-specific fucosylation
Fucosylated carbohydrate determinants are common components of cell surface glycoconjugates and secreted unconjugated glycans, which play pivotal roles in many physiological and pathological processes. The bio...
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Article
Open AccessExpansion and differentiation of human hepatocyte-derived liver progenitor-like cells and their use for the study of hepatotropic pathogens
The study of pathophysiological mechanisms in human liver disease has been constrained by the inability to expand primary hepatocytes in vitro while maintaining proliferative capacity and metabolic function. W...
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Article
Open AccessThe extent of liver injury determines hepatocyte fate toward senescence or cancer
It is well known that induction of hepatocyte senescence could inhibit the development of hepatocellular carcinoma (HCC). Until now, it is still unclear how the degree of liver injury dictates hepatocyte senes...
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Article
Open AccessInsulin-like growth factor 2 is a key mitogen driving liver repopulation in mice
Hepatocyte transplantation holds great promise as an alternative to orthotopic organ transplantation in the treatment of liver diseases. However, obtaining clinically meaningful levels of liver repopulation ha...
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Article
Open AccessEstablishment of a novel human lymphoblastic cell strain with the long arm of chromosome 11 aberration without MLL rearrangement
At present, all cell strains derived from acute lymphoblastic leukemia (ALL) patients with the long arm of chromosome 11 aberration are accompanied with mixed lineage leukemia (MLL) gene rearrangement. In this st...
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Article
Open AccessProtective effect of calcitonin on lumbar fusion-induced adjacent-segment disc degeneration in ovariectomized rat
Intervertebral disc (IVD) degeneration and pathological changes in the spinal cord are major causes of back pain. In addition to its well-established anti-resorptive effect on bone, calcitonin (CT) potentially...
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Article
Three-Dimensional Finite Element Analysis and Comparison of a New Intramedullary Fixation with Interlocking Intramedullary Nail
This study was set to introduce a new intramedullary fixation, explore its biomechanical properties, and provide guidance for further biomechanical experiments. With the help of CT scans and finite element mod...
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Article
Carbohydrate-based cancer vaccines: target cancer with sugar bullets
With the booming development of glycobiology and glycochemistry, more and more structures of tumor-associated carbohydrate antigens (TACAs) are identified. Their broad expression and high specificity in cancer...
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Article
Comparative ecophysiological responses to drought of two shrub and four tree species from karst habitats of southwestern China
Drought stress is one of the most important factors in limiting the survival and growth of plants in the harsh karst habitats of southwestern China, especially at the seedling establishment stage. The ecophysi...
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Erratum to: Exploitation of patchy soil water resources by the clonal vine Ficus tikoua in karst habitats of southwestern China
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Article
Exploitation of patchy soil water resources by the clonal vine Ficus tikoua in karst habitats of southwestern China
The karst habitats of southwestern China are characterized by a highly heterogeneous distribution of water resources. We hypothesized that the clonal integration between connected ramets of the clonal vine Ficus ...
