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Article
Author Correction: MYC phase separation selectively modulates the transcriptome
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Article
MYC phase separation selectively modulates the transcriptome
Dysregulation and enhanced expression of MYC transcription factors (TFs) including MYC and MYCN contribute to the majority of human cancers. For example, MYCN is amplified up to several hundredfold in high-risk n...
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Article
Fluorogenic reporter enables identification of compounds that inhibit SARS-CoV-2
The coronavirus SARS-CoV-2 causes the severe disease COVID-19. SARS-CoV-2 infection is initiated by interaction of the viral spike protein and host receptor angiotensin-converting enzyme 2 (ACE2). We report an...
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Article
Open AccessEnhancing intracellular accumulation and target engagement of PROTACs with reversible covalent chemistry
Current efforts in the proteolysis targeting chimera (PROTAC) field mostly focus on choosing an appropriate E3 ligase for the target protein, improving the binding affinities towards the target protein and the...
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Article
Open AccessIntrabody-based FRET probe to visualize endogenous histone acetylation
Post-translational histone modifications are major regulators of gene expression. However, conventional immunoassays do not provide sufficient information regarding their spatial and temporal dynamic changes. ...
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Article
Open AccessDemonstration of protein-fragment complementation assay using purified firefly luciferase fragments
Human interactome is predicted to contain 150,000 to 300,000 protein-protein interactions, (PPIs). Protein-fragment complementation assay (PCA) is one of the most widely used methods to detect PPI, as well as ...
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Chapter and Conference Paper
The Effects of Molecular Structure on the Melt Rheology of Low Density Polyethylene
A rapid method for obtaining information on average molecular weights, molecular weight distribution, molecular size, and long chain branching (LCB) characteristics of low density polyethylene (LDPE) from gel-...
