5 Result(s)
within
Cesare Patrone
Biomedicine
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Article
Open AccessA High-Fat Diet Increases Activation of the Glucagon-Like Peptide-1-Producing Neurons in the Nucleus Tractus Solitarii: an Effect that is Partially Reversed by Drugs Normalizing Glycemia
Glucagon-like peptide-1 (GLP-1) is a peripheral incretin and centrally active peptide produced in the intestine and nucleus tractus solitarii (NTS), respectively. GLP-1 not only regulates metabolism but also i...
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Article
Open AccessThe Stroke-Induced Increase of Somatostatin-Expressing Neurons is Inhibited by Diabetes: A Potential Mechanism at the Basis of Impaired Stroke Recovery
Type 2 diabetes (T2D) hampers recovery after stroke, but the underling mechanisms are mostly unknown. In a recently published study (Pintana et al. in Clin Sci (Lond) 133(13):1367–1386, 2019), we showed that i...
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Article
Open AccessType 2 diabetes impairs odour detection, olfactory memory and olfactory neuroplasticity; effects partly reversed by the DPP-4 inhibitor Linagliptin
Recent data suggest that olfactory deficits could represent an early marker and a pathogenic mechanism at the basis of cognitive decline in type 2 diabetes (T2D). However, research is needed to further charact...
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Article
Open AccessGLP-1 secretion by microglial cells and decreased CNS expression in obesity
Type 2 diabetes (T2D) is a strong risk factor for develo** neurodegenerative pathologies. T2D patients have a deficiency in the intestinal incretin hormone GLP-1, which has been shown to exert neuroprotectiv...
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Chapter
A Cellular Model for the Study of Estrogen Activity in Cells of Neural Origin
It is well known that estrogens play a major role in the sexual differentiation of the brain (1, 2), in the control of sex-related behaviour and endocrine functions linked to the reproduction. Therefore, estro...
