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Chapter
Estrogen Neuroprotective Activity After Stroke and Spinal Cord Injury
Morphological studies have revealed that in mammals the brain is a sexually dimorphic organ and are responsible for brain masculinization which occur perinatally. These morphological differences underline si...
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Article
Open AccessDietary essential amino acids restore liver metabolism in ovariectomized mice via hepatic estrogen receptor α
In female mammals, the cessation of ovarian functions is associated with significant metabolic alterations, weight gain, and increased susceptibility to a number of pathologies associated with ageing. The mole...
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Article
Open AccessInhibition of microglial β-glucocerebrosidase hampers the microglia-mediated antioxidant and protective response in neurons
Homozygotic mutations in the GBA gene cause Gaucher’s disease; moreover, both patients and heterozygotic carriers have been associated with 20- to 30-fold increased risk of develo** Parkinson’s disease. In h...
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Article
Open AccessInhibition of SIRT1 deacetylase and p53 activation uncouples the anti-inflammatory and chemopreventive actions of NSAIDs
Nonsteroidal anti-inflammatory drugs (NSAIDs) have been proposed as chemopreventive agents for many tumours; however, the mechanism responsible for their anti-neoplastic activity remains elusive and the side e...
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Article
Open AccessIdentification of the allosteric P2X7 receptor antagonist [11C]SMW139 as a PET tracer of microglial activation
The P2X7 receptor plays a significant role in microglial activation, and as a potential drug target, the P2X7 receptor is also an interesting target in positron emission tomography. The current study aimed at the...
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Article
Open AccessSelective proliferative response of microglia to alternative polarization signals
Microglia are resident myeloid cells of the central nervous system (CNS) that are maintained by self-renewal and actively participate in tissue homeostasis and immune defense. Under the influence of endogenous...
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Article
Open AccessNovel Locally Active Estrogens Accelerate Cutaneous Wound Healing-Part 2
Estrogen deprivation is associated with delayed healing, while estrogen replacement therapy (ERT) accelerates acute wound healing and protects against development of chronic wounds. However, current estrogenic...
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Article
Open AccessLiver ERα regulates AgRP neuronal activity in the arcuate nucleus of female mice
Recent work revealed the major role played by liver Estrogen Receptor α (ERα) in the regulation of metabolic and reproductive functions. By using mutant mice with liver-specific ablation of Erα, we here demonstra...
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Article
Open AccessSelf-renewal and phenotypic conversion are the main physiological responses of macrophages to the endogenous estrogen surge
Beyond the physiology of reproduction, estrogen controls the homeostasis of several tissues. Although macrophages play a key role in tissue remodeling, the interplay with estrogen is still ill defined. Using a...
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Chapter
Erratum to: Sexual Dimorphism and Estrogen Action in Mouse Liver
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Chapter
Sexual Dimorphism and Estrogen Action in Mouse Liver
Recent studies have demonstrated that in mice, the estrogen receptor alpha (ERα) is expressed in the liver and has a direct effect on the regulation of the hepatic genes relevant for energy metabolism and drug...
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Chapter
Estrogen Neuroprotective Activity After Stroke and Spinal Cord Injury
Morphological studies have revealed that in mammals the brain is a sexually dimorphic estrogen are responsible for brain masculinization which occur perinatally. These morphological differences underline sig...
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Article
Open AccessEstrogen accelerates the resolution of inflammation in macrophagic cells
Although 17β-estradiol (E2) anti-inflammatory activity has been well described, very little is known about the effects of this hormone on the resolution phase of the inflammatory process. Here, we identified a pr...
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Protocol
Reporter Mice for the Study of Long-Term Effects of Drugs and Toxic Compounds
Noninvasive, imaging-based methodologies provide for the first time the possibility to spatio-temporally investigate physiopathological events and long-term effects of drug administration of exposure to environme...
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Article
Energy metabolism and fertility—a balance preserved for female health
Metabolic and reproductive pathways are tightly associated, and this relationship has been conserved throughout evolution
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Article
Global Profiling of TSEC Proliferative Potential by the Use of a Reporter Mouse for Proliferation
“Tissue-selective estrogen complex” or TSEC is a novel concept of estrogen replacement therapy for the postmenopause based on the combined use of estrogens and selective estrogen receptor modulators (SERMs). T...
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Protocol
Profiling of Drug Action Using Reporter Mice and Molecular Imaging
Reporter mice associated to molecular imaging represent a major asset for the study of the spatio-temporal effects of drugs in living animals. The field is still relatively young and so far the number of animals ...
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Article
Silver paper: The future of health promotion and preventive actions, basic research, and clinical aspects of age-related disease
Background. In September 2008, under the French Presidency of the European Union and with the support of the Polish Minister of Health, a European Summit on Age-Related Disease was organi...
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Article
European silver paper on the future of health promotion and preventive actions, basic research, and clinical aspects of age-related disease
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Protocol
Reporter Mice for the Study of Intracellular Receptor Activity
During the past decade the remarkable progress in molecular genetics and the possibility to engineer cells to express genes reporting on the activity of specific promoters has produced major changes in biologi...
