3 Result(s)
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Article
Open AccessProjecting genetic associations through gene expression patterns highlights disease etiology and drug mechanisms
Genes act in concert with each other in specific contexts to perform their functions. Determining how these genes influence complex traits requires a mechanistic understanding of expression regulation across d...
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Article
Open AccessDiurnal rhythms of wrist temperature are associated with future disease risk in the UK Biobank
Many chronic disease symptomatologies involve desynchronized sleep-wake cycles, indicative of disrupted biorhythms. This can be interrogated using body temperature rhythms, which have circadian as well as slee...
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Article
Open AccessA Pilot Characterization of the Human Chronobiome
Physiological function, disease expression and drug effects vary by time-of-day. Clock disruption in mice results in cardio-metabolic, immunological and neurological dysfunction; circadian misalignment using f...
