5 Result(s)

Article

Projecting genetic associations through gene expression patterns highlights disease etiology and drug mechanisms

Genes act in concert with each other in specific contexts to perform their functions. Determining how these genes influence complex traits requires a mechanistic understanding of expression regulation across d...

Milton Pividori, Sumei Lu, Binglan Li, Chun Su, Matthew E. Johnson… in Nature Communications (2023)

Article

Author Correction: The high-dimensional space of human diseases built from diagnosis records and mapped to genetic loci

Gengjie Jia, Yu Li, Xue Zhong, Kanix Wang, Milton Pividori… in Nature Computational Science (2023)

Article

The high-dimensional space of human diseases built from diagnosis records and mapped to genetic loci

Human diseases are traditionally studied as singular, independent entities, limiting researchers’ capacity to view human illnesses as dependent states in a complex, homeostatic system. Here, using time-stamped...

Gengjie Jia, Yu Li, Xue Zhong, Kanix Wang, Milton Pividori… in Nature Computational Science (2023)

Article

Discerning asthma endotypes through comorbidity map**

Asthma is a heterogeneous, complex syndrome, and identifying asthma endotypes has been challenging. We hypothesize that distinct endotypes of asthma arise in disparate genetic variation and life-time environme...

Gengjie Jia, Xue Zhong, Hae Kyung Im, Nathan Schoettler… in Nature Communications (2022)

Article

Polygenic transcriptome risk scores (PTRS) can improve portability of polygenic risk scores across ancestries

Polygenic risk scores (PRS) are valuable to translate the results of genome-wide association studies (GWAS) into clinical practice. To date, most GWAS have been based on individuals of European-ancestry leadin...

Yanyu Liang, Milton Pividori, Ani Manichaikul, Abraham A. Palmer… in Genome Biology (2022)