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Article
Origins and Progression of Adolescent Endometriosis
Accumulating evidence indicates that adolescent endometriosis is common and often severe. Here we explore the possibility that seeding of naive endometrial progenitor cells into the pelvic cavity early in life...
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Article
Role of Label-Retaining Cells in Estrogen-Induced Endometrial Regeneration
Candidate stem/progenitor cells have been identified in mouse endometrium as label-retaining cells (LRCs). The role of endometrial stem/progenitor cells in initiating estrogen-stimulated endometrial growth in ...
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Article
Priorities for Endometriosis Research: Recommendations From an International Consensus Workshop
Endometriosis is an estrogen-dependent disorder where endometrial tissue forms lesions outside the uterus. Endometriosis affects an estimated 10% of women in the reproductive-age group, rising to 30% to 50% in...
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Article
Stem Cells in Human Reproduction
The derivation of human embryonic stem (hES) cells heralds a new era in stem cell research, generating excitement for their therapeutic potential in regenerative medicine. Pioneering work of embryologists, dev...
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Article
Expression of Steroid Receptor Coactivators in Cultured Cells From Paired Myometrial and Fibroid Tissues
Fibroid tumor growth in the myometrium appears to be regulated by estrogens but the role of estrogen receptor (ER) coregulators, such as the steroid receptor coactivator (SRC) family members, in fibroid growth...
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Article
Estrogen Receptor-α Agonists Promote Angiogenesis in Human Myometrial Microvascular Endothelial Cells
The relative role of the two estrogen receptors, ERα and ERβ, in mediating angiogenic responses in adult human endothelium is unknown. Tlte aim of this study was to determine whether novel ERα-selective agonis...