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Article
Open AccessT lymphocyte senescence is attenuated in Parkinson’s disease
Immune involvement is well-described in Parkinson’s disease (PD), including an adaptive T lymphocyte response. Given the increasing prevalence of Parkinson’s disease in older age, age-related dysregulation of ...
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Article
Open AccessThe effects of single and a combination of determinants of anaemia in the very old: results from the TULIPS consortium
Nutritional deficiencies, renal impairment and chronic inflammation are commonly mentioned determinants of anaemia. The aim of this study was to investigate the effects of these determinants, singly and in com...
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Article
Mediterranean diet and the hallmarks of ageing
Ageing is a multifactorial process associated with reduced function and increased risk of morbidity and mortality. Recently, nine cellular and molecular hallmarks of ageing have been identified, which characte...
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Article
Open AccessPublisher Correction: A meta-analysis of genome-wide association studies identifies multiple longevity genes
A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-22613-2
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Article
Open AccessCMV-independent increase in CD27−CD28+ CD8+ EMRA T cells is inversely related to mortality in octogenarians
Cytomegalovirus (CMV) seropositivity in adults has been linked to increased cardiovascular disease burden. Phenotypically, CMV infection leads to an inflated CD8 T-lymphocyte compartment. We employed a 8-colou...
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Article
Open AccessA meta-analysis of genome-wide association studies identifies multiple longevity genes
Human longevity is heritable, but genome-wide association (GWA) studies have had limited success. Here, we perform two meta-analyses of GWA studies of a rigorous longevity phenotype definition including 11,262...
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Article
Open AccessTelomere length is associated with childhood trauma in patients with severe mental disorders
Reduced telomere length (TL) and structural brain abnormalities have been reported in patients with schizophrenia (SZ) and bipolar disorder (BD). Childhood traumatic events are more frequent in SZ and BD than ...
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Reference Work Entry In depth
Role of Immunosenescence in Coronary Artery Disease
This chapter describes how previous infection with cytomegalovirus (CMV) leads to a senescent phenotype of the adaptive immune system, mainly inflating the CD8 T cell compartment, and how this is linked to vas...
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Living Reference Work Entry In depth
Role of Immunosenescence in Coronary Artery Disease
This chapter describes how previous infection with cytomegalovirus (CMV) leads to a senescent phenotype of the adaptive immune system, mainly inflating the CD8 T-cell compartment, and how this is linked to vas...
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Article
Open AccessParietal white matter lesions in Alzheimer’s disease are associated with cortical neurodegenerative pathology, but not with small vessel disease
Cerebral white matter lesions (WML) encompass axonal loss and demyelination, and the pathogenesis is assumed to be small vessel disease (SVD)-related ischemia. However, WML may also result from the activation ...
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Article
Open AccessEarly-life adversity accelerates cellular ageing and affects adult inflammation: Experimental evidence from the European starling
Early-life adversity is associated with accelerated cellular ageing during development and increased inflammation during adulthood. However, human studies can only establish correlation, not causation, and exi...
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Article
Open AccessAge-related frailty and its association with biological markers of ageing
The relationship between age-related frailty and the underlying processes that drive changes in health is currently unclear. Considered individually, most blood biomarkers show only weak relationships with fra...
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Article
Neuropathologically mixed Alzheimer’s and Lewy body disease: burden of pathological protein aggregates differs between clinical phenotypes
Multiple different pathological protein aggregates are frequently seen in human postmortem brains and hence mixed pathology is common. Mixed dementia on the other hand is less frequent and neuropathologically sho...
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Article
Open AccessUtility of NT-proBNP as a rule-out test for left ventricular dysfunction in very old people with limiting dyspnoea: the Newcastle 85+ Study
Guidelines advocate using B-type natriuretic peptides in the diagnostic work-up of suspected heart failure (HF). Their main role is to limit echocardiography rates by ruling out HF/LV dysfunction where peptide...
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Article
Acquisition of aberrant DNA methylation is associated with frailty in the very old: findings from the Newcastle 85+ Study
Frailty is a major health problem in older people and, as the population ages, identification of its underlying biological mechanisms will be increasingly important. DNA methylation patterns within genomic DNA...
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Article
Inflammation, Telomere Length, and Grip Strength: A 10-year Longitudinal Study
Telomere attrition has been associated with age-related diseases, although causality is unclear and controversial; low-grade systemic inflammation (inflammaging) has also been implicated in age-related pathoge...
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Article
Open AccessCapability and dependency in the Newcastle 85+ cohort study. Projections of future care needs
Little is known of the capabilities of the oldest old, the fastest growing age group in the population. We aimed to estimate capability and dependency in a cohort of 85 year olds and to project future demand f...
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Article
Association of mitochondrial haplogroup J and mtDNA oxidative damage in two different North Spain elderly populations
This work investigates the association between longevity, mitochondrial DNA (mtDNA) variants and oxidative DNA damage in an older than 85 years population. The participants, similar in genetic and cultural bac...
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Article
Open AccessThe Newcastle 85+ study: biological, clinical and psychosocial factors associated with healthy ageing: study protocol
The UK, like other developed countries, is experiencing a marked change in the age structure of its population characterised by increasing life expectancy and continuing growth in the older fraction of the pop...
